Abstract
Although suprapontine brain is not necessary for normal breathing patterns and responses to chemical and other stimuli, it is known that neurons in the mesencephalon and thalamus do under some conditions develop a rhythmic pattern of firing that has the timing of the respiratory cycle1, 2. We became interested in the question because of observations we had made in unanesthetized, decerebrate, vagotomized cats. Some mesencephalic neurons, which fired irregularly or tonically when Pco2 was low and phrenic activity small, developed a respiratory-linked rhythm when respiratory activity had been increased by electrical stimulation of a carotid sinus nerve. The present studies were designed to investigate systematically the characteristics and source of the respiratory-associated neuronal rhythm3, 4.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Vibeit, J.F., Caille, D., Bertrand, F., Gromysz, H., and Hugelin, A., Ascending projection from the respiratory centre to mesencephalon and diencephalon. Neuroscience Letten 11:29(1979).
Orem, J., and Nctick, A., Characteristics of midbrain respiratory neurons in sleep and wakefulness in the cat, Brain Research 244:231 (1982).
Chen, Z., Eldridge, F.L., and Wagner, P.G., Respiratory-associated rhythmic firing of midbrain neurons in cats: Relation to level of respiratory drive, J. Physiol. (London) 437:305 (1991).
Chen, Z., Eldridge, F.L., and Wagner, P.G., Respiratory associated rhythmic firing of thalamic neurons: Relation to level of respiratory drive, FASEB J. 5:A666 (1991).
Hobson, JA., and Steriade, M., Neuronal basis of behavioral control. In Handbook of Physoiology, section 1, The Nervous System, Vol. IV American Physiol. Soc., Bethesda, MD, USA, pp. 701–803 (1986).
Kumagai, H., Sakai, F., Sakuma, A., and Hukuhara, T., Relationship between activity of respiratory center and EEG. Ptog. Brain Res. 21:98 (1966).
Davenport, P.W., Friedman, WA, Thompson, F J., and Franzen, O., Respiratory-related cortical potentials evoked by inspiratory occlusion in humans. J. Appl. Physiol. 60:1843(1986).
Banzett, R.B., Lansing, R.W., Reid, M.B., Adams, L., and Brown, L. “Air hunger” arising from increased Pco2 in mechanically ventilated quadriplegics, respir. Physiol. 76:53 (1989).
Gleeson, K., Zwillich, C.W., Ventilation, arousal from sleep, and adenosine stimulation., Climical Res. 38:790A (1990)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Eldridge, F.L., Chen, Z., Wagner, P.G. (1992). Respiratory-Associated Firing of Midbrain and Thalamic Neurons: Possible Relation to Sensation of Dyspnea. In: Honda, Y., Miyamoto, Y., Konno, K., Widdicombe, J.G. (eds) Control of Breathing and Its Modeling Perspective. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9847-0_28
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9847-0_28
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9849-4
Online ISBN: 978-1-4757-9847-0
eBook Packages: Springer Book Archive