Respiratory-Associated Firing of Midbrain and Thalamic Neurons: Possible Relation to Sensation of Dyspnea
Although suprapontine brain is not necessary for normal breathing patterns and responses to chemical and other stimuli, it is known that neurons in the mesencephalon and thalamus do under some conditions develop a rhythmic pattern of firing that has the timing of the respiratory cycle1, 2. We became interested in the question because of observations we had made in unanesthetized, decerebrate, vagotomized cats. Some mesencephalic neurons, which fired irregularly or tonically when Pco2 was low and phrenic activity small, developed a respiratory-linked rhythm when respiratory activity had been increased by electrical stimulation of a carotid sinus nerve. The present studies were designed to investigate systematically the characteristics and source of the respiratory-associated neuronal rhythm3, 4.
KeywordsObstructive Sleep Apnea Respiratory Drive Respiratory Rhythm Thalamic Neuron Carotid Sinus Nerve
Unable to display preview. Download preview PDF.
- 3.Chen, Z., Eldridge, F.L., and Wagner, P.G., Respiratory-associated rhythmic firing of midbrain neurons in cats: Relation to level of respiratory drive, J. Physiol. (London) 437:305 (1991).Google Scholar
- 4.Chen, Z., Eldridge, F.L., and Wagner, P.G., Respiratory associated rhythmic firing of thalamic neurons: Relation to level of respiratory drive, FASEB J. 5:A666 (1991).Google Scholar
- 5.Hobson, JA., and Steriade, M., Neuronal basis of behavioral control. In Handbook of Physoiology, section 1, The Nervous System, Vol. IV American Physiol. Soc., Bethesda, MD, USA, pp. 701–803 (1986).Google Scholar
- 8.Banzett, R.B., Lansing, R.W., Reid, M.B., Adams, L., and Brown, L. “Air hunger” arising from increased Pco2 in mechanically ventilated quadriplegics, respir. Physiol. 76:53 (1989).Google Scholar
- 9.Gleeson, K., Zwillich, C.W., Ventilation, arousal from sleep, and adenosine stimulation., Climical Res. 38:790A (1990)Google Scholar