Hypoxic Depression of Respiration

  • Neil S. Cherniack
  • Jyoti Mitra
  • Nanduri R. Prabhakar


Hypoxia is one of the more common and serious stresses challenging homeostasis. Apart from its effects on specialized O2 sensing chemoreceptors, hypoxia has direct effects on all the tissues of the body. The tissues of the central nervous system (CNS) are probably the most vulnerable to the injurious actions of low levels of oxygen. Because of the importance of the CNS as an organizer of integrated responses, CNS reactions to subnormal oxygenation underlie the responses of the body as a whole to acute and chronic hypoxia. The response of the CNS to hypoxia is of obvious importance in unraveling the mechanisms that participate in altitude adaptation, diseases which produce global hypoxia (chronic lung disease of the adult and infant), and diseases which produce local cerebral hypoxia (cerebral ischemia and convulsive disorders).


Sympathetic Activity Phrenic Nerve Sympathetic Nerve Activity Carotid Body Sodium Cyanide 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Neil S. Cherniack
    • 1
  • Jyoti Mitra
    • 1
  • Nanduri R. Prabhakar
    • 1
  1. 1.Departments of Medicine and Physiology and BiophysicsCase Western Reserve University School of MedicineClevelandUSA

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