A Mathematical Model of the Ventilatory Response to a Period of Sustained Isocapnic Hypoxia in Humans

  • Rosemary Painter
  • Saeed Khamnei
  • Peter Robbins

Abstract

The human ventilatory response to a period of isocapnic hypoxia is biphasic, with a fast initial increase in ventilation after the step into hypoxia, followed by a slower decline towards its initial value. At the end of the hypoxic period there is another rapid change in ventilation but the decrease is not as great as the initial increase. We have developed a mathematical model to describe the response to hypoxia, taking into account the rapid changes in ventilation at the steps of Po2, the gradual decline, and the asymmetry between the on and the off responses.

Keywords

Ventilatory Response Peripheral Component Generate Model Data Hypoxic Period Model Minus Data 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    S. Khamnei and P.A. Robbins, Hypoxic depression of ventilation in humans: alternative models for the chemoreflexes, Respir. Physiol. 81:117–134(1990).PubMedCrossRefGoogle Scholar
  2. 2.
    B.B. Lloyd, M.G.M. Jukes and D.J.C. Cunningham, The relation between alveolar oxygen pressure and the respiratory response to carbon dioxide in man, Q. J. Exp. Physiol. 43:214–226 (1958).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Rosemary Painter
    • 1
  • Saeed Khamnei
    • 1
  • Peter Robbins
    • 1
  1. 1.University Laboratory of PhysiologyOxfordUK

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