Role of Cl--HCO3- Exchanger and Anion Channel in the Cat Carotid Body Function

  • Rodrigo Iturriaga
  • Sukhamay Lahiri


Carotid body (CB) chemosensory responses to respiratory and metabolic acidosis are well demonstrated both in vivo and in vitro 1. The responses are expected to originate from the chemoreceptor cells which usually should manifest parallel phenomena. The consensus model of the chemoreceptor unit is that the glomus cells are the presynaptic chemoreceptor cells and the sensory fibers are the postsynaptic elements which, we supposed, should reflect the events in the presynaptic glomus cells. However, Buckler et al.2 and Wilding et al.3 reported that the glomus cells possessed at least three ion-exchangers which regulated the intracellular pH (pHi). If the chemosensory responses are coupled to the pHj of the glomus cell and its pHi is well regulated then there will be a lack of correspondence between the glomus cell pHi and the sensory response to CO2-H+. Accordingly the role of the ion-exchangers would appear ambivalent.


Carotid Body Glomus Cell Carotid Sinus Nerve Chemosensory Response Chemoreceptor Cell 
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  1. 1.
    C. Eyzaguirre, R. S. Fitzgerald, S. Lahiri, and P. Zapata, Arterial Chemoreceptors, in: Handbook of Physiology. The Cardiovascular System, Peripheral Circulation and Organ Flow, American Physiol Soc, Williams and Wilkins, Baltimore, p. 557–621 (1983).Google Scholar
  2. 2.
    K. J. Buckler, R.D. Vaughan-Jones, C. Peers and P.C.G. Nye, Intracellular pH and its regulation in the isolated type I carotid body cells of the neonatal rat, J. Physiol. Lond., 436: 107–129 (1991).PubMedGoogle Scholar
  3. 3.
    T. J. Wilding, B. Cheng, and A, Roos, The relationship between extracellular pH (pHo) and intracellular pH (pHi) in adult rat carotid body glomus cells, Biophys. J., 59: 184a (1991).Google Scholar
  4. 4.
    A. Roos, and W.F. Boron, Intracellular pH, Physiol Rev., 61: 296–434 (1984).Google Scholar
  5. 5.
    A. Stea, and C. Nurse, Chloride channels in cultured glomus cells of the rat carotid body, Am. J. Physiol., 257: C174–C181 (1989).PubMedGoogle Scholar
  6. 6.
    R. Iturriaga, W.L. Rumsey, A. Mokashi, D. Spergel, D.F. Wilson, and S. Lahiri, In vitro perfused-superfused cat carotid body for physiological and pharmacological studies, J. Appl. Physiol., 70: 1393–1400 (1991).PubMedGoogle Scholar
  7. 7.
    R. Iturriaga, and S. Lahiri, Carotid body chemoreception in the absence and presence of CO2-HCO3 -, Brain Res., 568: 253–260 (1991).PubMedCrossRefGoogle Scholar
  8. 8.
    M. Shirahata, and R.S. Fitzgerald, The presence of CO2/HCO3 - is essential for hypoxic chemotransduction in the in vivo perfused carotid body, Brain Res., 545: 297–300 (1991).PubMedCrossRefGoogle Scholar
  9. 9.
    R. Iturriaga, W.L. Rumsey, S. Lahiri, D. Spergel, and D.F. Wilson, Intracellular pH and O2 chemoreception in the cat carotid body, J. Appl. Physiol., 72: (1992). (In press).Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Rodrigo Iturriaga
    • 1
  • Sukhamay Lahiri
    • 1
  1. 1.Department of Physiology, School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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