Dynamical Analysis of the Ventilatory Response to Changes in Peto2: Separation of Central and Peripheral Effects

  • A. Berkenbosch
  • J. DeGoede
  • C. N. Olievier
  • D. S. Ward


In adult humans and animals as well as in newborns the ventilatory response to an isocapnic stepwise change in end-tidal PO2 (PETO2) shows an initial fast increase frequently followed by a slow decline.1, 2, 3, 4, 5 The ventilatory increase is generally ascribed to an increased drive from the peripheral chemoreceptors. The mechanism of the subsequent hypoxic ventilatory depression is not well understood.6 To gain insight into the mechanism of this depression it is necessary to first separate and quantify stimulatory and depressant effects. An attractive technique to do this is the dynamic end-tidal forcing (DEF) technique, since it is non-invasive and can therefore be applied to human beings. However, for the dynamical analysis of the experimental data a mathematical model is needed, the validation of which is not easy a task.


Depressant Effect Ventilatory Response Peripheral Effect Artificial Perfusion Peripheral Chemoreceptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    S. Kagawa, MJ. Stafford, T.B. Waggener, and J.W. Severinghaus, No effect of naloxone on hypoxia-induced ventilatory depression in adults, J. Appl. Physiol. 52: 1030 (1982).PubMedGoogle Scholar
  2. 2.
    E.E. Lawson, and W.A. Long, Central origin of triphasic breathing pattern during hypoxia in newborns J. Appl. Physiol. 55: 483 (1983).PubMedGoogle Scholar
  3. 3.
    P.A. Easton, L.J. Slykerman, and N.R. Anthonisen, Ventilatory response to sustained hypoxia in normal adults, J. Appl. Physiol. 61: 906 (1986).PubMedGoogle Scholar
  4. 4.
    M. Vizek, C.K. Pickett, and J.V. Weil, Biphasic ventilatory response of adult cats to sustained hypoxia has central origin, J. Appl. Physiol 63: 1658 (1987).PubMedGoogle Scholar
  5. 5.
    A. Suzuki, M. Nishimura, H. Yamamoto, K. Miyamoto, F. Kishi, and Y. Kawakami, No effect of brain blood flow on ventilatory depression during sustained hypoxia, J. Appl. Physiol. 66: 1674 (1989).PubMedGoogle Scholar
  6. 6.
    A. Berkenbosch, and J. DeGoede, Effects of brain hypoxia on ventilation, Eur. Respir. J. 1: 184 (1988).PubMedGoogle Scholar
  7. 7.
    J. DeGoede, N. VanDerHoeven, A. Berkenbosch, C.N. Olievier, and J.H.G.M. VanBeek, Ventilatory response to sudden isocapnic changes in end-tidal O2 in cats, in: Modelling and Control of Breathing. B.J. Whipp and D.M. Wiberg, ed., Elsevier, New York, (1983).Google Scholar
  8. 8.
    D.S. Ward, A. Berkenbosch, J. DeGoede, and C.N. Olievier, Dynamics of the ventilatory response to central hypoxia in cats, J. Appl. Physiol. 68: 1107 (1990).PubMedGoogle Scholar
  9. 9.
    A. Berkenbosch, J. DeGoede, D.S. Ward, C.N. Olievier, and J. VanHartevelt, Dynamic response of the peripheral chemoreflex loop to changes in end-tidal O2, J. Appl. Physiol. 71: 1123 (1991).PubMedGoogle Scholar
  10. 10.
    A. Berkenbosch and J. DeGoede, Actions and interactions of CO2 and O2 on central and peripheral chemoreceptive structures, in: Neurobiology of the Control of Breathing. C. von Euler and H. Lagercrantz, ed., Raven Press, New York, (1986).Google Scholar
  11. 11.
    A. Berkenbosch, J. Heeringa, C.N. Olievier, and E.W. Kruyt, Artificial perfusion of the pontomedullary region of cats. A method for separation of central an peripheral effects of chemical stimulation of ventilation, Respir. Physiol. 37: 347 (1979).PubMedCrossRefGoogle Scholar
  12. 12.
    J. DeGoede, A. Berkenbosch, D.S. Ward, J.W. Bellville, and C.N. Olievier, 1985, Comparison between chemoreflex gains obtained with two different methods in cats, J. Appl. Physiol 59: 170 (1985).PubMedGoogle Scholar
  13. 13.
    P. Dejours, Chemoreflexes in breathing, Physiol. Rev. 42: 335 (1962).PubMedGoogle Scholar
  14. 14.
    W.N. Gardner, The pattern of breathing following step changes of alveolar partial pressures of carbon dioxide and oxygen in man, J. Physiol. 300: 55 (1980).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • A. Berkenbosch
    • 1
  • J. DeGoede
    • 1
  • C. N. Olievier
    • 1
  • D. S. Ward
    • 2
  1. 1.Department of PhysiologyUniversity of LeidenLeidenThe Netherlands
  2. 2.Department of AnesthesiologyUniversity of CaliforniaLos AngelesUSA

Personalised recommendations