Dynamics of Synaptic Plasticity: A Comparison between Models and Experimental Results in Visual Cortex

  • Brian Blais
  • Harel Shouval
  • Leon N. Cooper

Abstract

Receptive fields in the visual cortex can be altered by changing the visual environment, as has been shown many times in deprivation experiments. In this paper we simulate this set of experiments using two different models of cortical plasticity, BCM and PCA. The visual environment used is composed of natural images for open eye and of noise for closed eyes. We measure the response of the neurons to oriented stimuli, and use the time course information of the neuronal response to provide a preliminary quantitative comparison between the cortical models and experiment.

Keywords

Visual Cortex Synaptic Plasticity Receptive Field Visual Environment Striate Cortex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. [l]
    E. L. Bienenstock, L. N. Cooper, and R W. Munro. Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex. Journal Neuroscience, 2: 32–48, 1982.Google Scholar
  2. [2]
    C. Blakemore and R. R. van Sluyters. Reversal of the physiological effects of monocular deprivation in kittens: further evidence for sensitive period. J. Phvsiol. Land., 248: 663–716, 1974.Google Scholar
  3. [3]
    E. E. Clothiaux, L. N Cooper, and M. F. Bear. Synaptic plasticity in visual cortex: Comparison of theory with experiment. Journal of Neurophysiology, 66: 1785–1804, 1991.PubMedGoogle Scholar
  4. [4]
    R. Freeman, R. Mallach, and S. Hartley. Responsivity of normal kitten striate cortex deteriorates after brief binocular deprivation. Journal of Neurophysiology, 45 (6): 1074–1084, 1981.PubMedGoogle Scholar
  5. [5]
    R. Freeman and C. Olson. Brief periods of monocular deprivation in kittens: Effects of delay prior to physiological study. Journal of Neurophysiology, 47 (2): 139–150, 1982.PubMedGoogle Scholar
  6. [6]
    Y. Frégnac and M. Imbert. Development of neuronal selectivity in the primary visual cortex of the cat. Physiol. Rev., 64: 325–434, 1984.PubMedGoogle Scholar
  7. [7]
    D. H. Hubel and T. N. Wiesel. Receptive fields, binocular interaction and functional architecture in the cat’s visual cortex. J. Physiol, 160: 106–154, 1962.PubMedGoogle Scholar
  8. [8]
    N. Intrator and L. N. Cooper. Objective function formulation of the BCM theory of visual cortical plasticity: Statistical connections, stability conditions. Neural Networks, 5: 3–17, 1992.CrossRefGoogle Scholar
  9. [9]
    C. Law and L. Cooper. Formation of receptive fields according to the BCM theory in realistic visual environemnts. Proceedings National Academy of Sciences, 91: 7797–7801, 1994.CrossRefGoogle Scholar
  10. [10]
    L. Mioche and W. Singer. Chronic recording from single sites of kitten striate cortex during experience-dependent modification of synaptic receptive-field properties. J NeurophysioL, 62: 185–197, 1989.PubMedGoogle Scholar
  11. [11]
    E. Oja. A simplified neuron model as a principal component analyzer. Journal of Mathematical Biology, 15: 267–273, 1982.PubMedCrossRefGoogle Scholar
  12. [12]
    H. Shouval and Y. Liu. How does retinal preprocessing Affect the Receptive field of a stabilized hebbian neuron. In J. M. Bower, editor, The Neurobiology of Computation: The Proceedings of the Third Annual Computation and Neural Systems confrence, pages 129–134. Kluwer, 1994.Google Scholar
  13. [13]
    T. N. Wiesel and D. H. Hubel. Single-cell responses in striate cortex of kittens deprived of vision in one eye. Journal of Neurophysiology, 26: 1003–1017, 1963.PubMedGoogle Scholar
  14. [14]
    J. L. Wyatt and I. M. Elfadel. Time-domain solutions of Oja’s equations. Neural Computation, 7 (5): 915–922, 1995.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Brian Blais
    • 1
  • Harel Shouval
    • 1
  • Leon N. Cooper
    • 1
  1. 1.The Department of Physics The Institute for Brain and Neural SystemsBrown UniversityProvidenceUSA

Personalised recommendations