Integrate-and-Fire Neurons Matched to Physiological F-I Curves Yield High Input Sensitivity and Wide Dynamic Range

  • Todd W. Troyer
  • Kenneth D. Miller


Simple integrate-and-fire neurons that accurately reproduce in vitro data from cortical regular spiking cells can display surprisingly sophisticated behavior. To reproduce in vitro f-I plots, voltage after spikes was reset to 5 mV below threshold, and simple spike rate adaptation was added. Small reset results in input sensitivity (high gain) on short time scales; adaptation leads to wide dynamic range over longer time scales. The model displays physiological ISI variability using either delta function or temporally realistic synaptic conductances. Cross correlation between pre- and post-synaptic spikes suggests that cortical neurons may be capable of transmitting information on the millisecond time scale.


Firing Rate Spike Train Synaptic Input Steady State Regime Millisecond Time Scale 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Todd W. Troyer
    • 1
  • Kenneth D. Miller
    • 1
  1. 1.Keck Center for Integrative NeuroscienceUniversity of CaliforniaSan FranciscoUSA

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