Abstract
A fifteen compartment, biologically realistic model of a cerebellar granule cell (GC) was developed to examine the signal processing capabilities of this most numerous element in the cerebellar cortical circuit. The model explicitly includes compartments for the soma, axon hillock, proximal axon, dendrites and terminal bulbs. All synaptic inputs were transduced via activation of glutamate receptor subtypes located on the dendritic bulb compartments, and were systematically varied in their number and frequency. An intriguing morphological feature, in which axonal location is shifted from the soma to a dendrite, was specifically examined to determine its impact on granule cell output. The GC was shown to be electrotonically compact, resulting in a lack of biasing of output based on axonal location. Biasing of output could be driven by changes in the passive parameters of the model, but required an unrealistically large change in resistive coupling between dendritic and somal compartments. Thus, axonal location does not induce physiologically relevant phase shifts between synaptic inputs located on multiple dendritic bulbs, suggesting that the GC relies heavily upon temporal aspects of its input signals for integrative processing.
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References
Albus JS (1971) A theory of cerebellar function. Mathematical Biosciences 10: 25–61
Bardoni R and Bel luzzi O (1993) Kinetic study and numerical reconstruction of A-type current in granule cells of rat cerebellar slices..1 Neurophysiol 69: 2222–2231
Bloedel JR and Courville.1(1981) Cerebellar afferent systems. In: Brooks VB (ed), Handbook of Physiology. The Nervous System, pp. 735–830
Bower,IM and Beeman D (1994) The book of GENESIS: exploring realistic neural models with the GEneral NEural Simulation System. TELOS, Speinger-Verlag. New York.
Cull-Candy SG. Marshall CG and Ogden D (1989) Voltage-activated membrane currents in rat cerehellar granule neurones..l Physiol 414: 179–199
D’Angelo E. Rossi P and Gathwaite J (1990) Dual-component NMDA receptor currents at a single central synapse. Nature Lund 346: 467–470.
D’Angelo E, De Filippi G. Rossi P and Taglietti V (1995) Synaptic excitation of individual rat cerehellar granule cells in.situ: evidence for the role of NMDA receptors. J Physiol 484: 397–413
Fagni L, Bossu JL and Bockaert J (1991) Activation of a large-conductance Ca’’-dependent K’ channel by stimulation of glutamate phosphoinositide-coupled receptors in cultured cerebellar granule cells. Fur J Neurosci 3: 778–789
Gabbiani F, Midtgaard.1 and Knöpfel T (1994) Synaptic integration in a model of cerehellar granule cells. J Neurophysiol 72: 999–1009
Gorter JA. Aronica E. Hack NJ and Balazs R (1995) Developement of voltage-activated potassium currents in cul-
tured cerebellar granule neurons under defferent growth conditions. J Neurophysiol 74:298–306
Hausser M, Stuart G. Racca C and Sakmann B (1995) Axonal initiation and active dendritic propagation of action potentials in substantia nigra neurons. Neuron 15: 637–647
Lu H. Prior FW and Larson-Prior LJ (1995) Signal transduction in a cerebellar granule cell: a modeling approach. Neurosci Abstr 21: 916
Mugnaini E, Atluri RL and Houk JC (1974) Fine structure of granular layer in turtle cerebellum with emphasis on large glomeruli. J Neurophysiol 37: 1–29
Palay SL, Sotelo C, Peters A and Orkand PM (1968) The axon hillock and the initial segment. J. Cell Biol. 38: 193–201
Palay SL and Chan-Palay V (1974) Cerebellar cortex cytology and organization. Springer-Verlag, New York
Peters A,Proskauer CC and Kaiserman-Abramof IR (1968) The small pyramical neuron of the rat cerebral cortex. The axon hillock and initial segment. J. Cell Biol. 39:601–619
Silver RA, Traynelis SF and Cull-Candy GC (1992) Rapid-time-course miniature and evoked excitatory currents at cerebellar synapses in situ. Nature 355: 163–166
Sloper JJ and Powell TPS (1979) A study of the axon initial segment and proximal axon of neurons in the primate motor and somatic sensory cortices. Phil. Trans. Roy. Soc. (Lond) B 285: 173–197
Yamada WM. Koch C and Adams PR (1989) Multiple channels and calcium dynamics. In: Koch C and Segev I (eds) Methods in neuronal modeling from synapses to networks, pp 97–133
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Lu, H., Prior, F.W., Larson-Prior, L.J. (1997). Information Processing in a Cerebellar Granule Cell. In: Bower, J.M. (eds) Computational Neuroscience. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9800-5_19
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DOI: https://doi.org/10.1007/978-1-4757-9800-5_19
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