An Analysis of the Adaptive Behavior of Piriform Cortex Pyramidal Cells

  • S. M. Crook
  • G. B. Ermentrout


Cortical pyramidal neurons respond to a depolarizing current pulse with a train of action potentials [4, 2]. These action potentials occur at a higher frequency during the initial stages of the current injection with a decreased firing rate or a cessation of firing at later stages of a sustained injection. This spike frequency adaptation can be mostly suppressed by local application of norepinephrine or acetylcholine [6, 7] which block a slow calcium-dependent potassium current.


Pyramidal Cell Bifurcation Diagram Current Injection Saddle Node Bifurcation Maximal Conductance 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • S. M. Crook
    • 1
  • G. B. Ermentrout
    • 2
  1. 1.Mathematical Research Branch, NIDDKNational Institutes of HealthBethesdaUSA
  2. 2.Department of MathematicsUniversity of PittsburghPittsburghUSA

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