Improvement in Resolution with Nonlinear Methods Applied to NMR Signals from Macromolecules

  • A. Polichetti
  • P. Barone
  • V. Viti
  • L. Fiume
Part of the NATO ASI Series book series (NSSA, volume 225)


Spectral estimators alternative to the Fast Fourier Transform have elicited a great deal of interest for performing the spectral anaylsis of NMR signals in time domain. In our approach, we used Prony’s method, in connection with the covariance algorithm, to calculate the autoregressive coefficients. The main problem in the use of this method is the determination of the model order p. We have examined the behavior of the residuals as a function of p and then we studied the stability of the result around relative minima. We have applied this method to the 31P NMR signals from the antiviral drug ara-AMP conjugated to human lactosaminated albulmin as hepatotropic carrier, obtaining very high resolution spectra.


Fast Fourier Transform Model Order Free Induction Decay Relative Minimum High Resolution Spectrum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • A. Polichetti
    • 1
  • P. Barone
    • 2
  • V. Viti
    • 1
  • L. Fiume
    • 3
  1. 1.Istituto Superiore di SanitàLaboratorio di FisicaRomaItaly
  2. 2.Istituto Applicazioni del CalcoloCNRRomaItaly
  3. 3.Dipartimento di Patologia SperimentaleBolognaItaly

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