An Amateur Looks at Error Analysis in the Determination of Protein Structure by NMR

  • Jeffrey C. Hoch
Part of the NATO ASI Series book series (NSSA, volume 225)


Error analysis constitutes an important part of experimental physical chemistry, yet many of the concepts taught at the undergraduate level have yet to be systematically applied to the determination of protein structure by NMR. At first glance, the application of such simple concepts to the complex problem of structure determination might appear quixotic. However, with straightforward extensions, these concepts can yield valuable insights into the precision of NMR based structures. Some of these concepts are explored, using illustrative examples from the data of Driscoll et al. (Biochemistry 20, 2188 (1989)) for the 43 residue protein BDS-I.


Trivial Solution Distance Restraint Hybrid Distance Plausible Structure Experimental Restraint 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Jeffrey C. Hoch
    • 1
  1. 1.Rowland Institute for ScienceCambridgeUSA

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