Human Hemostatic/Coagulation Mechanisms

  • Jessica H. Lewis


There are hundreds if not thousands of factors that have been shown to play some role in human hemostasis. This short discussion deals only with those that can be measured or easily detected and that appear to be analogous to hemostatic mechanisms in other mammals or lower vertebrates.


Tissue Factor Coagulation Pathway Fibrinogen Degradation Product Human Factor VIII Platelet Plug 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Davie, E. W., and Ratnoff, O. D., 1964, Waterfall sequence for intrinsic blood clotting, Science 145: 1310.PubMedCrossRefGoogle Scholar
  2. MacFarlane, R. G., 1964, An enzyme cascade in the blood clotting mechanism and its function as a biochemical amplifier, Nature (London) 202: 498.CrossRefGoogle Scholar

Suggested Readings

  1. Colman, R. W., Bagdasarian, A., Talamo, R. C., Scott, C. F., Seavey, M., Guinaraes, J. A., Pierce, J. F., and Kaplan, A. P., 1975, Williams trait: Human kininogen deficiency with diminished levels of plasminogen proactivator and prekallikrein associated with abnormalities of the Hage-man factor—dependent pathways, J. Clin. Invest. 56: 1650.PubMedCrossRefGoogle Scholar
  2. Comp, P. C., and Esmon, C. T., 1984, Recurrent venous thromboembolism in patients with a partial deficiency of protein S, N. Engl. J. Med. 311: 1525.PubMedCrossRefGoogle Scholar
  3. Doolittle, R. F., 1984, Fibrinogen and fibrin, Anno. Rev. Biochem. 53: 195.CrossRefGoogle Scholar
  4. Esmon, C. T., and Owen, W. G., 1981, Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C, Proc. Natl. Acad. Sci. U.S.A. 78: 2249.PubMedCrossRefGoogle Scholar
  5. Fulcher, C. A., Gardiner, J. E., Griffin, J. H., and Zimmerman, T. S., 1984, Proteolytic inactivation of human factor VIII procoagulant protein by activated human protein C and its analogy with factor V, Blood 63: 486.PubMedGoogle Scholar
  6. Furie, B., and Furie, B. C., 1988, The molecular basis of blood coagulation, Cell 53:505. Gilbert, G. E., Furie, B. C., and Furie, B., 1990, Binding of human factor VIII to phospholipid vesicles, J. Biol. Chem. 265: 815.Google Scholar
  7. Griffin, J. H., Evatt, B., Zimmerman, T. S., Kleiss, A. J., and Wideman, C., 1981, Deficiency of protein C in congenital thrombotic disease, J. Clin. Invest. 68: 1370.PubMedCrossRefGoogle Scholar
  8. Hathaway, W. E., Belhasen, L. P., and Hathaway, H. S., 1965, Evidence for a new plasma thromboplastin factor. I. Case report, coagulation studies and physiochemical properties, Blood 26: 521.PubMedGoogle Scholar
  9. Mann, K. G., Jenney, R. J., and Krishnaswamy, S., 1988, Cofactor proteins in the assembly and expression of blood clotting enzyme complexes, Annu. Rev. Biochem. 57: 915.PubMedCrossRefGoogle Scholar
  10. Naito, K., and Fujikawa, K., 1991, Activation of human blood coagulation factor XI independent of factor XII: Factor XI is activated by thrombin and factor XIa in the presence of negatively charged surfaces, J. Biol. Chem. 266: 7353.PubMedGoogle Scholar
  11. Osterud, B., and Rapaport, S. I., 1977, Activation of factor IX by the reaction product of tissue factor and factor VII: Additional pathway for initiating blood coagulation, Proc. Natl. Acad. Sci. U.S.A. 74: 5260.PubMedCrossRefGoogle Scholar
  12. Rao, L. V., and Rapaport, S. I., 1988, Activation of factor VII bound to tissue factor: A key early step in the tissue factor pathway of blood coagulation, Proc. Natl. Acad. Sci. U.S.A. 85: 6687.PubMedCrossRefGoogle Scholar
  13. Walker, F. J., Sexton, P. W., and Esmon, C. T., 1979, The inhibition of blood coagulation by activated protein C through the selective inactivation of activated factor V, Biochim. Biophys. Acta 571: 333.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Jessica H. Lewis
    • 1
  1. 1.University of Pittsburgh School of Medicine and Central Blood BankPittsburghUSA

Personalised recommendations