Skip to main content
SpringerLink
Log in

Comparative Hemostasis

  • Chapter
Book cover Comparative Hemostasis in Vertebrates

Abstract

The bleeding time is the time measured with a stopwatch between the making of a small incision in the skin and the moment the bleeding stops. Duke in 1910 was the first to describe, in humans, a bleeding time involving a cut on the fingertip or earlobe. Ivy in 1941 standardized the procedure to the making of a shallow cut with a new knife blade on the ventral surface of the forearm with a sphygmomanometer cuff on the upper arm inflated to 30–40 mm Hg. Mielka et al. (1969) developed a template to standardize the length and depth of the cut. Currently, most bleeding times done in humans involve a perpendicular cut on the cleaned volar surface of the forearm in an area without visible veins. A commercially available template, Simplate (OT), is most frequently used.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Breukind, H. J., Hart, H. C., Arkel, C., Velden, N. A., and Watering, C. C., 1972, Congenital afibrinogenemia in goats, Zentralbi. Veterinaermed. Reihe A 19: 661. 78.

    Google Scholar 

  • Didisheim, P., and Bunting, D. L., 1964, Canine hemophilia, Thromb. Diath. Haemorrh. 12:377. Lewis, J. H., Spero, J., and Hasiba, U., 1983, A hemophiliac dog colony: Genetic studies and coagulation findings in hemophiliac and normal dogs, Comp. Biochem. Physiol. 75: 147.

    Google Scholar 

  • Mielka, C. H., Kaneshiro, M. M., Maher, I. A., Weiner, J. M., Rapaport, S. I., 1969, The standardized normal ivy bleeding time and its prolongation by aspirin, Blood 34: 294.

    Google Scholar 

  • Thiele, G. L., Rempel, W. E., Fass, D. N., Bowie, E. J. W., Stewart, M., and Zoecklein, L., 1986, Inheritance of a new bleeding disease in a herd of swine with Willebrand’s disease, J. Hered. 77: 179.

    PubMed  CAS  Google Scholar 

Suggested Readings

  • Baillie, A. J., and Sim, A. K., 1971, Activation of the fibrinolytic enzyme system in laboratory animals and man—a comparative study, Thromb. Diath. Haemorrh. 25: 499.

    PubMed  CAS  Google Scholar 

  • Cliffton, E. E., and Cannamela, D. A., 1951, Variations in proteolytic activity of serum of animals including man, Proc. Soc. Exp. Biol. Med. 77: 305.

    PubMed  CAS  Google Scholar 

  • Hedlin, A. M., Monkhouse, F. C., and Milojevic, S. M., 1972, A comparative study of fibrinolytic activity in human, rat, rabbit and dog blood, Can. J. Physiol. Pharmacol. 50: 11.

    Article  PubMed  CAS  Google Scholar 

  • Irfan, M., 1968, Fibrinolytic activity in animals of different species, Q. J. Exp. Physiol. 53: 374.

    PubMed  CAS  Google Scholar 

  • Kowalski, E., Budzynski, A. Z., Kopec, M., Latallo, Z. S., Lipinski, B., and Wegrzynowicz, Z., 1964, Studies on the molecular pathology and pathogenesis of bleeding in severe fibrinolytic states in dogs, Thromb. Diath. Haemorr. 12: 69.

    CAS  Google Scholar 

  • Lewis, J. H., and Wilson, J. H., 1964, Fibrinogen breakdown products, Am. J. Physiol. 207: 1053.

    PubMed  CAS  Google Scholar 

  • Lewis, J. H., Szeto, I. F., Bayer, W. L., and Curiel, B. C., 1972, Leukofibrinolysis, Blood 40: 844.

    PubMed  CAS  Google Scholar 

  • Mason, R. G., and Read, M. S., 1971, Some species differences in fibrinolysis and blood coagulation, J. Biomed. Mater. Res. 5: 121.

    Article  PubMed  CAS  Google Scholar 

  • Todd, A. S., 1964, Localization of fibrinolytic activity in tissues, Br. Med. Bull. 20: 210.

    PubMed  CAS  Google Scholar 

  • Tsapogas, M. J., and Flute, P. J., 1964, Experimental thrombolysis with streptokinase and urokinase, Br. Med. Bull. 20: 223.

    CAS  Google Scholar 

  • Archer, R. K., 1961, True haemophilia (haemophilia A) in a thoroughbred foal, Vet. Rec. 73: 383.

    Google Scholar 

  • Archer, R. K., and Allen, B. V., 1972, True haemophilia in horses, Vet. Rec. 85: 655.

    Article  Google Scholar 

  • Archer, R. K., and Bowden, R. S., 1959, A case of true haemophilia in a Labrador dog, Vet. Rec. 71: 560.

    Google Scholar 

  • Aufderheid, W. M., Skinner, S. F., and Kaneko, J. J., 1975, Clearance of cryoprecipitated factor VIII in canine hemophilia A, Am. J. Vet. Res. 36: 367.

    Google Scholar 

  • Sellars, A. R. M., 1969, Hereditary disease in British Antarctic sledge dogs, Vet. Res. 85: 600.

    Google Scholar 

  • Benn, D. M., 1978, Classic hemophilia A in a family of collies, Can. Vet. J. 19: 221.

    PubMed  CAS  Google Scholar 

  • Benson, R. E., Bouma, B. N., and Dodds, W. J., 1975, Factor VIII—related antigen in canine hemophilia and von Willebrand’s disease: Variation when measured with different agaroses. Thromb. Res. 7: 383.

    Article  PubMed  CAS  Google Scholar 

  • Benson, R. E., Catalfamo, J. L., and Dodds, W. J., 1992, A multispecies enzyme-linked immunosorbent assay for von Willebrand’s factor, J. Lab. Clin. Med. 119: 420.

    PubMed  CAS  Google Scholar 

  • Bentino-Smith, J., Roberts, S. J., and Katz, E. M., 1960, A bleeding disease of newborn calves, Cornell Vet. 50: 15.

    Google Scholar 

  • Bird, R. M., Hampton, J. W., Lain, K. C., Brock, W. E., and Buckner, R. G., 1964, Mild canine hemophilia: Clinical and cytogenetic studies in females, Trans. Am. Clin. Climatol. Assoc. 76: 131.

    Google Scholar 

  • Bogart, R., and Muhrer, M. E., 1942, The inheritance of a hemophilia-like condition in swine, J. Hered. 33: 59.

    Google Scholar 

  • Bowie, E. J. W., Owen, C. A., Jr., Zollman, P. E., Thompson, J. H., Jr., and Fass, D. N., 1973, Tests of hemostasis in swine: Normal values in pigs affected with von Willebrand’s disease, Am. J. Vet. Res. 34: 1405.

    PubMed  CAS  Google Scholar 

  • Bowie, E. J. W., Woods, J. E., Fass, D. N., Zollman, P. E., and Owen, C. A., Jr., 1975, Liver transplantation in pigs with von Willebrand’s disease, Br. J. Haematol. 31: 37.

    Article  PubMed  CAS  Google Scholar 

  • Bowie, E. J., Fass, D. N., and Owen, C. A., 1980, Hemostatic effect of transfused Willebrand factor in porcine von Willebrand’s disease: Similarities to the human disease, Haemostasis 9: 352.

    PubMed  CAS  Google Scholar 

  • Bowie, E. J. W., Solberg, L. A., Jr., Fass, D. N., Johnson, C. M., Knutson, G. J., Stewart, M. L., and Zoecklein, L. J., 1986, Transplantation of normal bone marrow into a pig with severe von Willebrand’s disease, J. Clin. Invest. 78: 26.

    Article  PubMed  CAS  Google Scholar 

  • Brinkhous, K. M., and Graham, J. B., 1950, Hemophilia in the female dog, Science 111. 723.

    Article  PubMed  CAS  Google Scholar 

  • Brinkhous, K. M., Morrison, F. C., Jr., and Muhrer, M. E., 1952, Comparative study of clotting defects in human, canine, and porcine hemophilia, Fed. Proc. Fed. Am. Soc. Exp. Biol. 11: 409.

    Google Scholar 

  • Brinkhous, K. M., Davis, P. D., Graham, J. B., and Dodds, W. J., 1973, Expression and linkage of genes for X-linked hemophilias A and B, Blood 41: 577.

    PubMed  CAS  Google Scholar 

  • Brock, W. E., Buchner, R. G., Hampton, J. W., Bird, R. M., and Wulz, C. E., 1963, Canine hemophilia: Establishment of a new colony, Arch. Pathol. 76: 464.

    PubMed  CAS  Google Scholar 

  • Brown, R. C., Swanton, M. C., and Brinkhous, K. M., 1963, Canine hemophilia and male pseudohermaphroditism, Lab. Invest. 12: 961.

    PubMed  CAS  Google Scholar 

  • Brown, R. C., Cole, K. W., Cornell, C. N., and Brinkhous, K. M., 1968, Haemophilia-like disease in swine: Cytogenetic studies, Am. J. Vet. Res. 29: 1491.

    PubMed  CAS  Google Scholar 

  • Buckner, R. G., Hampton, J. W., Bird, R. M., and Brock, W. E., 1967, Hemophilia in the vizsla, J. Small Anim. Pract. 8: 511.

    Article  PubMed  CAS  Google Scholar 

  • Capel-Edwards, K., and Hall, D. E., 1968, Factor VII deficiency in the beagle dog, Lab. Anim. 2: 105.

    Article  Google Scholar 

  • Cook, W. R., 1974, Epistaxis in the racehorse, Equine Vet. J. 6: 45.

    Article  PubMed  CAS  Google Scholar 

  • Cornell, C. N., Cooper, R. G., Muhrer, M. E., and Garb, S., 1972, Splenectomy and factor VIII response in bleeder swine, Am. J. Phy-siol. 22: 1610.

    Google Scholar 

  • Cornell, C. N., Cooper, R. G., Muhrer, M. E., and Garb, S., 1972, Effect of plasma and platelet concentrate infusion on factor VIII, platelet adhesiveness, and bleeding time in bleeder swine, Thromb. Diath. Haemorrh. 28: 431.

    PubMed  CAS  Google Scholar 

  • Cotter, S. M., Brenner, R. M., and Dodds, W. J., 1978, Hemophilia A in three unrelated cats, J. Am. Vet. Med. Assoc. 172: 166.

    PubMed  CAS  Google Scholar 

  • Dam, H., 1934, Haemorrhages in chicks reared on artificial diets: A new deficiency disease, Nature (London) 133: 909.

    Article  CAS  Google Scholar 

  • Dodds, W. J., 1966, Familial canine thrombocytopathy, Blood 28: 1013.

    Google Scholar 

  • Dodds, W. J., 1967, Familial canine thrombocytopathy: Platelets: Their role in hemostasis and thrombosis, Thromb. Diath. Haemorrh. Suppl. 26: 241.

    PubMed  CAS  Google Scholar 

  • Dodds, W. J., 1968, Current concepts of hereditary coagulation disorders in dogs, Exp. Anim. 1: 243.

    Google Scholar 

  • Dodds, W. J., 1970, Congenital thrombopathies and related coagulation disorders in dogs, in: Proceedings of “Les mutants pathologiques chez l’animal, leur intérèt dans la recherche bio-médicale” ( M. Sabourdy, ed.), pp. 317–326, CNRS Press, Paris.

    Google Scholar 

  • Dodds, W. J., 1970, Canine von Willebrand’s disease, J. Lab. Clin. Med. 76: 713.

    PubMed  CAS  Google Scholar 

  • Dodds, W. J., 1971, Hemorrhagic disorders, in: Current Veterinary Therapy, 4th ed. ( R. W. Kird, ed.), p. 247, W. B. Saunders, Philadelphia.

    Google Scholar 

  • Dodds, W. J., 1973, Canine factor X (Stuart-Prower factor) deficiency, J. Lab. Clin. Med. 82: 560.

    PubMed  CAS  Google Scholar 

  • Dodds, W. J., 1974, Hereditary and acquired hemorrhagic disorders in animals, in: Progress in Hemostasis and Thrombosis, Vol. 2 ( T. H. Spaet, ed.), pp. 215–247, Grune and Stratton, New York.

    Google Scholar 

  • Dodds, W. J., 1975, Further studies in canine von Willebrand’s disease, Blood 45: 221.

    PubMed  CAS  Google Scholar 

  • Dodds, W. J., 1975, Inherited hemorrhagic disorders, J. Am. Anim. Hosp. Assoc. 11: 366.

    Google Scholar 

  • Dodds, W. J., and Blaisdell, F. S., 1972, Platelet and fibrinogen survivals in canine von Willebrand’s disease, Program of the 15th Meeting of the American Society of Hematology, Hollywood, FL.

    Google Scholar 

  • Dodds, W. J., and Kull, J. E., 1971, Canine factor XI (plasma thromboplastin antecedent) deficiency, J. Lab. Clin. Med. 78: 746.

    CAS  Google Scholar 

  • Dodds, W. J., Packham, M. A., Rowsell, H. C., and Mustard, J. F., 1967, Factor VII survival and turnover in dogs, Am. J. Physiol. 213: 36.

    PubMed  CAS  Google Scholar 

  • Dodds, W. J., Webster, W. P., Brinkhous, K. M., Owen, C. A., Jr., and Bowie, E. J. W., 1975, Porcine and canine von Willebrand’s disease, in: Handbook of Hemophilia ( K. M. Brinkhous and H. C. Hemker, eds.), pp. 140–147, Excerpta Medica, Amsterdam.

    Google Scholar 

  • Fass, D. N., Didisheim, P., Lewis, J. C., and Grabowski, E. F., 1976, Adhesion of porcine von Willebrand (VWD) platelets, Circ. Suppl. 54: 116 (abstract).

    Google Scholar 

  • Fass, D. N., Knutson, G. J., and Bowie, E. J. W., 1978, Porcine Willebrand factor: A population of multimers, J. Lab. Clin. Med. 91: 307.

    PubMed  CAS  Google Scholar 

  • Fass, D. N., Bowie, E. J. W., Owen, C. A., Jr., and Zollman, P. E., 1979, Inheritance of porcine von Willebrand’s disease: Study of a kindred of over 700 pigs, Blood 53: 712.

    PubMed  CAS  Google Scholar 

  • Fay, P. J., Cavallaro, C., Marder, V. J., Pancham, N., Fournel, M. A., and Schroeder, D. D., 1986, Comparison with the in vivo survival of human factor VIII with and without von Willebrand factor in the hemophilic dog, Thromb. Res. 37: 425.

    Article  Google Scholar 

  • Feldman, B. F., 1981, Coagulopathies in small animals, J. Am. Vet. Med. Assoc. 179: 559.

    PubMed  CAS  Google Scholar 

  • Feldman, B. F., and Giacopuzzi, R. L., 1982, Hemophilia A (factor VIII deficiency) in a colt, Equine Pract. 4: 24.

    Google Scholar 

  • Field, R. A., Rickard, C. G., and Hutt, F. B., 1946, Hemophilia in a family of dogs, Cornell Vet. 36: 283.

    Google Scholar 

  • Flute, P. T., and Howard, A. N., 1959, Blood coagulation in scorbutic guinea-pigs: A defect in activation by glass contact, Br. J. Haematol. 5: 421.

    Article  PubMed  CAS  Google Scholar 

  • Foster, V., Bowie, E. J. W., Lewis, J. C., Fass, D. N., Owen, C. A., and Brown, A. L., 1978

    Google Scholar 

  • Resistance to arteriosclerosis in pigs with von Willebrand’s disease, J. Clin. Invest. 61:722.

    Google Scholar 

  • Garner, R., Hermoso-Perez, C., and Conning, D. M., 1967, Factor VII deficiency in beagle dog plasma and its use in the assay of human factor VII, Nature (London) 216: 1130.

    Article  CAS  Google Scholar 

  • Gentry, P. A., 1977, Diagnosis of classic hemophilia A in a standard poodle, Can. Vet. J. 18: 79.

    PubMed  CAS  Google Scholar 

  • Gentry, P. A., Crane, S., and Lotz, F., 1975, Factor XI (plasma thromboplastin antecedent) deficiency in cattle, J. Can. Vet. Med. Assoc. 16: 160.

    CAS  Google Scholar 

  • Giles, A. R., Tinlin, S., and Greenwood, R., 1982, A canine model of hemophilic (factor VIII:C deficiency) bleeding, Blood 60: 727.

    PubMed  CAS  Google Scholar 

  • Graham, J. B., and Barrow, E. M., 1957, The pathogenesis of hemophilia, J. Exp. Med. 106: 273.

    Article  PubMed  CAS  Google Scholar 

  • Graham, J. B., Buckwalter, J. A., Hartley, L. J., and Brinkhous, K. M., 1949, Canine hemophilia: Observations on the course, the clotting anomaly, and the effect of blood transfusions, J. Exp. Med. 90: 97.

    Article  PubMed  CAS  Google Scholar 

  • Graham, J. B., Collins, D. L., Jr., Godwin, I. D., and Brinkhous, K. M., 1951, Assay of plasma antihemophilic activity in normal heterozygous (hemophilia) and prothrombopenic dogs, Proc. Soc. Exp. Biol. Med. 77: 294.

    PubMed  CAS  Google Scholar 

  • Graham, J. B., Brinkhous, K. M., and Dodds, W. J., 1975, Canine and equine hemophilia, in: Handbook of Hemophilia ( K. M. Brinkhous and H. C. Hemker, eds.), pp. 119–139, Excerpta Medica, Amsterdam.

    Google Scholar 

  • Green, R. A., and White, F., 1977, Feline factor XII (Hageman) deficiency, Am. J. Vet. Res. 38: 893.

    PubMed  CAS  Google Scholar 

  • Greenlee, J. C., and Carper, H. A., 1968, Blood coagulation. III. Hemophilia A, Am. J. Vet. Clin. Pathol. 2: 27.

    Google Scholar 

  • Griggs, T. R., Webster, W. P., Cooper, H. A., Wager, R. W., and Brinkhous, K. M., 1974, Von Willebrand factor: Gene dosage relationships and transfusion response in bleeder swine—a new bioassay, Proc. Natl. Acad. Sci. U.S.A. 71: 2087.

    Article  PubMed  CAS  Google Scholar 

  • Groth, C. G., Hathaway, W. E., Custafsson, A., Geis, W. P., Putnam, C. W., Bjorken, C., Porter, K. A., and Starzl, T. E., 1974, Correction of coagulation in the hemophilic dog by transplantation of lymphatic tissue, Surgery 75: 725.

    PubMed  CAS  Google Scholar 

  • Hall, D. E., 1972, Blood Coagulation and Its Disorders in the Dog,Williams and Wilkins, Baltimore.

    Google Scholar 

  • Hampton, J. W., Buckner, R. G.. Gunn, C. G., Miller, L. R., and Mayes, J. W., 1973, Canine hemophilia in beagles: Genetics, site of factor VIII synthesis and attempts at experimental therapy, in: Proceedings of the VII Congress of the World Federation of Haemophilia, ( F. Ala and K. W. E. Denson, eds.), p. 26, Excerpta Medica, Amsterdam.

    Google Scholar 

  • Hathaway, W. E., Mull, M. M., Githens, J. H., Groth, C. G., Marchioro, T. L., and Starzl, T. E., 1969, Attempted spleen transplant in classical hemophilia, Transplantation 7: 73.

    PubMed  CAS  Google Scholar 

  • Hegreberg, G. A., 1975, Animal model: Ehlers–Danlos syndrome in dogs and mink, canine cutaneous asthenia, Am. J. Pathol., 79: 383.

    PubMed  CAS  Google Scholar 

  • Hegreberg, G. A., Padgett, G. A., and Henson, J. B., 1970, Connective tissue disease of dogs and mink resembling the Ehlers–Danlos syndrome of man, Arch. Pathol. 90: 159.

    PubMed  CAS  Google Scholar 

  • Hinton, M., and Jones, D. R. E., 1977, A clotting defect in an Arab colt foal, Equine Vet. J. 9: 1.

    Article  PubMed  CAS  Google Scholar 

  • Hogan, A. G., Muhrer, M. E., and Bogart, R., 1941, A hemophilia-like disease in swine, Proc. Soc. Exp. Biol. Med. 48: 217.

    CAS  Google Scholar 

  • Hovig, T., Rowsell, H. C., Dodds, W. J., Jorgensen, L., and Mustard, J. F., 1967, Experimental hemostasis in normal dogs and dogs with congenital disorders of blood coagulation, Blood 30: 636.

    PubMed  CAS  Google Scholar 

  • Hovig, T., Dodds, W. J., Rowsell, H. C., and Mustard, J. F., 1968, The transformation of hemostatic platelet plugs in normal and factor IX deficient dogs, Am. J. Pathol. 53: 355.

    PubMed  CAS  Google Scholar 

  • Howard, A. N., and Flute, P. T., 1959, Defective blood coagulation in scorbutic guinea-pigs, Proc. Nutr. Soc. 18: 32.

    Article  Google Scholar 

  • Howell, J. M., and Lambert, P. S., 1964, A case of haemophilia A in the dog, Vet. Rec. 76: 1103.

    Google Scholar 

  • Hutchins, D. R., Lepherd, E. E., and Crook, 1. G., 1967, A case of equine hemophilia, Aust. Vet. J. 43: 83.

    Article  Google Scholar 

  • Hutt, F. B., Rickard, C. G., and Field, R. A., 1948, Sex-linked haemophilia in dogs, J. Hered. 39: 3.

    Google Scholar 

  • Jones, D. R. E., and Hill, F. W. G., 1974, Suspected thrombasthenia in a Shetland sheepdog, Vet. Rec. 94: 558.

    Article  PubMed  CAS  Google Scholar 

  • Kammeruran, B., Gmur, J., and Stunzi, H., 1971, Afibrinogenamie Beim Hund, Zentralbl. Veterinaermed. Reihe A 18: 192.

    Article  Google Scholar 

  • Kaneko, J. J., Cordy, D. R., and Carson, J., 1967, Canine hemophilia resembling classic hemophilia A, J. Am. Vet. Med. Assoc. 150: 15.

    Google Scholar 

  • Kier, A. B., Bresnahan, J. F., White, F. J., and Wagner, J. E., 1980, The inheritance pattern of factor XII (Hageman) deficiency in domestic cats, Can. J. Comp. Med. 44: 309.

    PubMed  CAS  Google Scholar 

  • Kociba, G. J., Ratnoff, O. D., Loeb, W. F., Wall, R. L., and Heider, L. E., 1969, Bovine plasma thromboplastin antecedent (factor XI) deficiency, J. Lab. Clin. Med. 74: 37.

    PubMed  CAS  Google Scholar 

  • Langdell, R. D., Wagner, R. H., and Brinkhous, K. M., 1955, Antihemophilic factor (AHF) levels following transfusions of blood, plasma, and plasma fractions, Proc. Soc. Exp. Biol. Med. 88: 212.

    PubMed  CAS  Google Scholar 

  • Lewis, E. F., and Holman, H. H., 1951, Haemophilia in a St. Bernard dog, Vet. Rec. 63: 666.

    Google Scholar 

  • Lewis, J. C., and Bowie, F. J. W., 1978, Ultrastructural studies of platelets of von Willebrand and normal swine, Mayo Clin. Proc. 53: 179.

    PubMed  CAS  Google Scholar 

  • McKinna, W. R., 1936, Haemophilia, Vet. J. 92: 370.

    Google Scholar 

  • Merkens, J., 1938, Haemophilie bu honden, Ned.-Ind. Bladen Diergeneeskd. Dierenteelt 50: 149.

    Google Scholar 

  • Mertz, E. T., 1942, The anomaly of a normal Duke’s and a very prolonged saline bleeding time in swine suffering from an inherited bleeding disease, Am. J. Physiol. 136: 360.

    Google Scholar 

  • Muhrer, M. E., Hogan, A. G., and Bogart, R., 1942, A defect in the coagulation mechanism of swine blood, Am. J. Physiol. 136: 355.

    Google Scholar 

  • Muhrer, M. E., Lechler, E., Cornell, C. N., and Kirkland, J. L., 1965, Antihemophilic factor levels in bleeder swine following infusions of plasma and serum, Am. J. Physiol. 208: 508.

    PubMed  CAS  Google Scholar 

  • Mustard, J. F., Rowsell, H. C., Robinson, G. A., Hoeksema, T. D., and Downie, H. G., 1960, Canine haemophilia B (Christmas disease), Br. J. Haematol. 6: 259.

    Article  PubMed  CAS  Google Scholar 

  • Mustard, J. F., Basser, W., Hedgardt, G., Secord, D., Rowsell, H. C., and Downie, H. G., 1962, A comparison of the effect of serum and plasma transfusions on the clotting defect in canine haemophilia B, Br. J. Haematol. 8: 36.

    Article  PubMed  CAS  Google Scholar 

  • Mustard, J. F., Secord, D., Hoeksema, T. D., Downie, H. G., and Rowsell, H. C., 1962, Canine factor VII deficiency, Br. J. Haematol. 8: 43.

    Article  PubMed  CAS  Google Scholar 

  • Myers, L. J., Pierce, K. R., Gowing, G. M., and Leonpacker, R. J., 1972, Hemorrhagic diathesis resembling pseudohaemophilia in a dog, J. Am. Vet. Med. Assoc. 161: 1028.

    PubMed  CAS  Google Scholar 

  • Nichols, T. C., Bellinger, D. A., Reddick, R. L., Read, M. S., Koch, G. G., Brinkhous, K. M., and Griggs, T. R., 1991, Role of von Willebrand factor in arterial thrombosis: Studies in normal and von Willebrand disease pigs, Circulation 83:íV-56.

    Google Scholar 

  • Norman, J. C., Covelli, V. H., and Sise, H. S., 1968, Transplantation of the spleen: Experimental cure of hemophilia, Surgery 64: 1.

    PubMed  CAS  Google Scholar 

  • Nossel, H., Archer, R. K., and MacFarlaine, R. G., 1962, Equine haemophilia: Report of a case and its response to multiple transfusions of hetrospecific AHG, Br. J. Haematol. 8: 355.

    Article  Google Scholar 

  • Osbaldiston, G. W., 1974, Hemophilia in the cat, Bull. Am. Soc. Vet. Clin. Pathol. 3: 64.

    Google Scholar 

  • Osweiler, G. D., Prankratz, D. C., Prasse, K. W., Stahr, H. M., and Buck, W. B., 1970, Porcine hemorrhagic disease, Mod. Vet. Pract. 51: 35.

    Google Scholar 

  • Owen, C. A., Jr., Bowie, E. J. W., Zollman, P. E., Fass, D. N., and Gordon, H., 1974, Carrier of porcine von Willebrand’s disease, Am. J. Vet. Res. 35: 245.

    PubMed  Google Scholar 

  • Parks, B. J., Brinkhous, K. M., Harris, P. F., and Penick, G. D., 1969, Laboratory detection of female carriers of canine hemophilia, Thromb. Diath. Haemorrh. 12: 368.

    Google Scholar 

  • Poller, L., Thomson, J. M., Sear, C. H. J., and Thomas, W., 1971, Identification of a congenital defect of factor VII in a colony of beagle dogs: The clinical use of the plasma, J. Clin. Pathol. 24: 626.

    Article  PubMed  CAS  Google Scholar 

  • Reddick, R. L., Griggs, T. R., Lamb, M. A., and Brinkhous, K. M., 1982, Platelet adhesion to damaged coronary arteries: Comparison of normal and von Willebrand diseased swine, Proc. Natl. Acad. Sci. U.S.A. 79: 5076.

    Article  PubMed  CAS  Google Scholar 

  • Rowsell, H. C., 1963, Hemorrhagic disorders in dogs: Their recognition, treatment and importance, in: The Newer Knowledge about Dogs, Twelfth Gaines Veterinary Symposium, p. 9.

    Google Scholar 

  • Rowsell, H. C., Downie, H. G., Mustard, J. F., Leeson, J. E., and Archibald, J. A., 1960, A disorder resembling hemophilia B (Christmas disease) in dogs, J. Am. Vet. Med. Assoc. 137: 347.

    Google Scholar 

  • Sanger, V. L., Mairs, R. E., and Trapp, A. L., 1964, Haemophilia in a foal, J. Am. Vet. Med. Assoc. 144: 259.

    PubMed  CAS  Google Scholar 

  • Saunders, C. N., Kinch, D. A., and Imlah, P., 1966, Thrombocytopenic purpura in pigs, Vet. Rec. 79: 549.

    Google Scholar 

  • Sawada, Y., Fass, D. N., Katzmann, J. A., Bahn, R. C., and Bowie, E. J. W., 1986, Hemostatic plug formation in normal and von Willegrand pigs: The effect of the administration of cryoprecipitate and a monoclonal antibody to Willebrand factor, Blood 67: 1229.

    PubMed  CAS  Google Scholar 

  • Schofield, F. W., 1924, Damaged sweet clover: The cause of a new disease in cattle simulating haemorrhagic septicaemia and blackleg, J. Am. Vet. Med. Assoc. 64: 553.

    Google Scholar 

  • Sharp, A. A., and Dike, G. W. R., 1963, Haemophilia in the dog: Treatment with heterologous anti-haemophilic globulin, Thromb. Diath. Haemorrh. 10: 494.

    Google Scholar 

  • Sherwood, L., Schmidt, D. A., Brett, I. J., and Howard, D. L., 1966, Canine hemophilia due to antihemophilic factor deficiency: A case report, Mich. State Univ. Vet. 26: 52.

    Google Scholar 

  • Slappendahl, R. J., 1975, Hemophilia A and B in a family of French bulldogs, Tijdschr. Diergeneeskd. 100: 1075.

    Google Scholar 

  • Spurling, N. W., Burton, L. K., Peacock, R., and Pilling, T., 1972, Hereditary factor VII deficiency in the beagle, Br. J. Haematol. 23: 59.

    Article  PubMed  CAS  Google Scholar 

  • Spurling, N. W., Burton, L. K., and Pilling, T., 1974, Canine factor-VII deficiency: Experience with a modified thrombotest method in distinguishing between the genotypes, Res. Vet. Sci. 16: 228.

    PubMed  CAS  Google Scholar 

  • Spurling, N. W., Peacock, R., and Pilling, T., 1974, The clinical aspects of canine factor-VII deficiency including some case histories, J. Small Anim. Pract. 15: 229.

    Article  PubMed  CAS  Google Scholar 

  • Storb, R., Marchioro, T. L., Graham, M. W., Hougie, C., and Thomas, E. D., 1972, Canine hemophilia and hemopoietic grafting, Blood 40: 234.

    PubMed  CAS  Google Scholar 

  • Stormorken, H., Egeberg, O., and Austad, R., 1965, Haemophilia A in Samoyed dog, Scand. J. Haematol. 2: 174.

    Article  Google Scholar 

  • Stuart, M. J., 1975, Inherited defects of platelet function, Semin. Hematol. 12: 233.

    PubMed  CAS  Google Scholar 

  • Swanton, M. C., 1959, Hemophilic arthropathy in dogs, Lab. Invest. 8: 1269.

    PubMed  CAS  Google Scholar 

  • Taskin, J., 1935, Un cas grave d’hémophylie chez une chienne, Bull. Acad. Vet. Fr. 8: 595.

    Google Scholar 

  • Tschopp, T. B., and Zucker, M. B., 1972, Hereditary defect in platelet function in rats, Blood 40: 217.

    PubMed  CAS  Google Scholar 

  • Veltkamp, J. J., Asfaou, E., van de Torren, K., van der Does, J. A., van Tilburg, N. H., and Pauwels, E. K. J., 1974, Extrahepatic factor VIII synthesis: Lung transplants in hemophilic dogs, Transplantation 18: 56.

    Article  PubMed  CAS  Google Scholar 

  • Wagner, R. H., Langdell, R. D., Richardson, B. A., Farrell, R. A., and Brinkhous, K. M., 1957, Antihemophilic factor (AHF): Plasma levels after administration of AHF preparations to hemophilic dogs, Proc. Soc. Exp. Biol. Med. 96: 152.

    PubMed  CAS  Google Scholar 

  • Weaver, R. A., Price, R. E., and Langdell, R. D., 1964, Antihemophilic factor in cross-circulated normal and hemophilic dogs, Am. J. Physiol. 206: 335.

    PubMed  CAS  Google Scholar 

  • Webster, W. P., Penick, G. D., Peacock, E. E., and Brinkhous, K. M., 1967, Allotransplantation of spleen in hemophilia, N. C. Med. J. 28: 505.

    Google Scholar 

  • Webster, W. P., Mandel, S. R., Reddick, R. L., Wagner, J. L., and Penick, G. D., 1974, Orthotopic liver transplantation in canine hemophilia B, Am. J. Physiol. 226: 496.

    PubMed  CAS  Google Scholar 

  • Webster, W. P., Dodds, W. J., Mandel, S. R., and Penick, G. D., 1975, Biosynthesis of factors VIII and IX: Organ transplantation and perfusion studies, in: Handbook of Hemophilia ( K. M. Brinkhous and H. C. Hemker, eds.), pp. 149–164, Excerpta Medica, Amsterdam.

    Google Scholar 

  • White, J. M., and Holm, G. C., 1965, Colony of hemophilic dogs, Science 150: 1766.

    Article  PubMed  CAS  Google Scholar 

  • Wurzel, H. A., and Lawrence, W. C., 1961, Canine hemophilia, Thromb. Diath. Haemorrh. 6: 98.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University of Pittsburgh School of Medicine and Central Blood Bank, Pittsburgh, Pennsylvania, USA

    Jessica H. Lewis

Authors
  1. Jessica H. Lewis
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer Science+Business Media New York

About this chapter

Cite this chapter

Lewis, J.H. (1996). Comparative Hemostasis. In: Comparative Hemostasis in Vertebrates. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9768-8_27

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-9768-8_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9770-1

  • Online ISBN: 978-1-4757-9768-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation