The high concentration and ubiquitous distribution of cholesterol in human tissues generate concern for the sterol’s function. Searches for function reviewed by Flint in 1862  continue to this day. The role of cholesterol as precursor of bile acids and steroid hormones is clearly established as is also its role in membrane integrity and function, and the association of cholesterol or its esters with several major health afflictions is well demonstrated, such matters as gallstones, hyperlipidemia, atherosclerosis, etc., being prominent. However, a polemic continues to exist regarding whether cholesterol be cause or effect in human disease.
KeywordsChapter VIII Sterol Biosynthesis Cholesterol Oxidation Product Exogenous Cholesterol Autoxidation Product
Unable to display preview. Download preview PDF.