Cholesterol (cholest-5-en-3β-ol) (1), the chief sterol of mammalian tissues and obligate precursor of steroid hormones and bile salts, has received much attention to its chemistry and biochemistry, to its role in membrane integrity and function, and to its association with human diseases such as atherosclerosis, gallstones, and cancer. The relationships between cholesterol and human disorders have attracted interest for over two centuries and date from the work of Vallisneri [2545] in 1733 on the properties of human gallstones, from which cholesterol was ultimately isolated. An association between cholesterol deposits and human aortal plaque formation was well recognized by 1847 [2597], and several other relations of cholesterol to pathological states were summarized in 1862 [779].


Free Sterol Sulfate Ester Autoxidation Product Cholesterol Derivative Infant Feces 
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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Leland L. Smith
    • 1
  1. 1.The University of Texas Medical BranchGalvestonUSA

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