Intracellular Cl Regulation and Synaptic Inhibition in Vertebrate and Invertebrate Neurons

  • Francisco J. Alvarez-Leefmans


Cl movements across plasma membrane channels and carriers play a central role in a number of mechanisms essential for neuronal function and survival. These include regulation and maintenance of intracellular pH (Boron, 1983; Thomas, 1984; see Russell and Boron, this volume), regulation and maintenance of cell volume (Ballanyi and Grafe, 1988; see Chapter 2, this volume), and modulation of neuronal excitability through anion channels activated by inhibitory neurotransmitters (Alger, 1985; Barker, 1985; Roberts, 1986; Siggins-Gruol, 1986), intracellular Ca2+ (see Mayer et al.,this volume), or transmembrane voltage (see Chesnoy-Marchais, this volume). Furthermore, Cl has recently been shown to exert modulatory effects on G proteins (Deterre et al., 1983; Higashijima et al., 1987). The latter are known to be an essential part of the intracellular messenger machinery coupling receptor binding of neurotransmitters (or hormones) to their specific cell responses. All the above considerations make evident the importance of understanding the mechanisms by which Cl is regulated and maintained in nerve cells. Given the wide spectrum of the subjects involved, the present account will be confined to considering Cl regulation in relation to inhibitory neurotransmitter actions.


Presynaptic Inhibition Dorsal Root Ganglion Cell Synaptic Inhibition Squid Giant Axon Primary Afferent Depolarization 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Francisco J. Alvarez-Leefmans
    • 1
    • 2
  1. 1.Departamento de Farmacología y ToxicologíaCentro de Investigacíon y de Estudios Avanzados del I. P. N.Mexico D. F.Mexico D. F.
  2. 2.Departamento de NeurobiologíaInstituto Mexicano de PsiquiatríaMexico D. F.Mexico

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