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Intracellular Cl− Regulation and Synaptic Inhibition in Vertebrate and Invertebrate Neurons

  • Chapter
Chloride Channels and Carriers in Nerve, Muscle, and Glial Cells

Abstract

Cl− movements across plasma membrane channels and carriers play a central role in a number of mechanisms essential for neuronal function and survival. These include regulation and maintenance of intracellular pH (Boron, 1983; Thomas, 1984; see Russell and Boron, this volume), regulation and maintenance of cell volume (Ballanyi and Grafe, 1988; see Chapter 2, this volume), and modulation of neuronal excitability through anion channels activated by inhibitory neurotransmitters (Alger, 1985; Barker, 1985; Roberts, 1986; Siggins-Gruol, 1986), intracellular Ca2+ (see Mayer et al.,this volume), or transmembrane voltage (see Chesnoy-Marchais, this volume). Furthermore, Cl− has recently been shown to exert modulatory effects on G proteins (Deterre et al., 1983; Higashijima et al., 1987). The latter are known to be an essential part of the intracellular messenger machinery coupling receptor binding of neurotransmitters (or hormones) to their specific cell responses. All the above considerations make evident the importance of understanding the mechanisms by which Cl− is regulated and maintained in nerve cells. Given the wide spectrum of the subjects involved, the present account will be confined to considering Cl− regulation in relation to inhibitory neurotransmitter actions.

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  1. Departamento de Farmacología y Toxicología, Centro de Investigacíon y de Estudios Avanzados del I. P. N., Mexico D. F., 07000, Mexico D. F.

    Francisco J. Alvarez-Leefmans

  2. Departamento de Neurobiología, Instituto Mexicano de Psiquiatría, Mexico D. F., 14370, Mexico

    Francisco J. Alvarez-Leefmans

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  1. Francisco J. Alvarez-Leefmans
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  1. Departamento de Farmacología y Toxicología, Centro de Investigación y de Estudios Avanzados del IPN, 07000, Mexico, D.F., USA

    Francisco J. Alvarez-Leefmans

  2. Departamento de Neurobiología, Instituto Mexicano de Psiquiatría, 14370, Mexico, D.F., USA

    Francisco J. Alvarez-Leefmans

  3. Department of Physiology and Biophysics, University of Texas Medical Branch, 77550, Galveston, Texas, USA

    John M. Russell

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Alvarez-Leefmans, F.J. (1990). Intracellular Cl− Regulation and Synaptic Inhibition in Vertebrate and Invertebrate Neurons. In: Alvarez-Leefmans, F.J., Russell, J.M. (eds) Chloride Channels and Carriers in Nerve, Muscle, and Glial Cells. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9685-8_4

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