Abstract
The resting membrane conductance of amphibian and mammalian skeletal muscle is largely due to Cl− ions (Hodgkin and Horowicz, 1959; Hutter and Noble, 1960; Palade and Barchi, 1977). This large anion conductance appears to stabilize muscle transmembrane voltage, as muscles with reduced Cl− conductance exhibit myotoniclike trains of action potentials which lead to aberrant muscle function (Adrian and Bryant, 1974). A comprehensive review of Cl— conductances in skeletal muscle and many other tissues has been provided by Bretag (1987). This chapter will focus only on mammalian and amphibian Cl− channels at the single-channel level as observed with the patch voltage-clamp technique (Hamill et al., 1981).
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Blatz, A.L. (1990). Chloride Channels in Skeletal Muscle. In: Alvarez-Leefmans, F.J., Russell, J.M. (eds) Chloride Channels and Carriers in Nerve, Muscle, and Glial Cells. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9685-8_16
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DOI: https://doi.org/10.1007/978-1-4757-9685-8_16
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