Chloride Channels in Skeletal Muscle

  • Andrew L. Blatz


The resting membrane conductance of amphibian and mammalian skeletal muscle is largely due to Cl ions (Hodgkin and Horowicz, 1959; Hutter and Noble, 1960; Palade and Barchi, 1977). This large anion conductance appears to stabilize muscle transmembrane voltage, as muscles with reduced Cl conductance exhibit myotoniclike trains of action potentials which lead to aberrant muscle function (Adrian and Bryant, 1974). A comprehensive review of Cl conductances in skeletal muscle and many other tissues has been provided by Bretag (1987). This chapter will focus only on mammalian and amphibian Cl channels at the single-channel level as observed with the patch voltage-clamp technique (Hamill et al., 1981).


Voltage Step Membrane Patch Mammalian Skeletal Muscle Amphibian Skeletal Muscle Hyperpolarizing Voltage Step 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Andrew L. Blatz
    • 1
  1. 1.Department of PhysiologyUniversity of Texas Southwestern Medical CenterDallasUSA

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