Chloride Channels in Skeletal Muscle
The resting membrane conductance of amphibian and mammalian skeletal muscle is largely due to Cl− ions (Hodgkin and Horowicz, 1959; Hutter and Noble, 1960; Palade and Barchi, 1977). This large anion conductance appears to stabilize muscle transmembrane voltage, as muscles with reduced Cl− conductance exhibit myotoniclike trains of action potentials which lead to aberrant muscle function (Adrian and Bryant, 1974). A comprehensive review of Cl— conductances in skeletal muscle and many other tissues has been provided by Bretag (1987). This chapter will focus only on mammalian and amphibian Cl− channels at the single-channel level as observed with the patch voltage-clamp technique (Hamill et al., 1981).
KeywordsVoltage Step Membrane Patch Mammalian Skeletal Muscle Amphibian Skeletal Muscle Hyperpolarizing Voltage Step
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