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Chemists’ Views of Imaging Centers pp 419–424Cite as

Radiofluorinated Enzyme Probes of Dopaminergic Function

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Abstract

Radiofluorinated analogs of enzyme substrates offer a useful strategy for designing radiotracers to probe or label specific enzymes and their function (1). They are being used to investigate the dopaminergic system in vivo to obtain information about the structural requirements associated with neurotransmitter enzyme function as well as critical information about pharmacological information and the effects of disease. Radiofluorinated enzyme probes (e.g. 6-[18F]fluoro-L-DOPA) have been useful to uncover the biochemical mechanisms behind specific brain tracer kinetic profiles and to understand kinetic changes occurring with the specifically designed radiotracers as a result of pharmacological interventions, centrally acting drugs (i.e., methamphetamine, cocaine), mood disorders or cell degeneration.

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Authors and Affiliations

  1. Department of Molecular and Medical Pharmacology and Laboratory of Structural Biology and Molecular Medicine, UCLA School of Medicine, Los Angeles, California, 90024, USA

    Jorge R. Barrio, N. Satyamurthy, M. Namavari & G. Lacan

Authors
  1. Jorge R. Barrio
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  2. N. Satyamurthy
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  3. M. Namavari
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  4. G. Lacan
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Editors and Affiliations

  1. Health Science Center, The University of Texas, Houston, Texas, USA

    Ali M. Emran

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© 1995 Springer Science+Business Media New York

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Barrio, J.R., Satyamurthy, N., Namavari, M., Lacan, G. (1995). Radiofluorinated Enzyme Probes of Dopaminergic Function. In: Emran, A.M. (eds) Chemists’ Views of Imaging Centers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9670-4_45

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  • DOI: https://doi.org/10.1007/978-1-4757-9670-4_45

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9672-8

  • Online ISBN: 978-1-4757-9670-4

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