Solid Phase Reagents in Radiosynthesis

  • G. Keith Mulholland
  • Douglas M. Jewett
Chapter

Abstract

Radiochemists rely heavily upon functionalized polymers and chromatographic supports for rapid isolation of radiochemicals and labeled intermediates. Extending the use of solid phase reagents from separation steps to radiolabeling reactions and organic transformations has many potential benefits; solid phase methods can shorten overall synthesis times, simplify chemical apparatus, and minimize use of hazardous solvents and reagents. The ability to localize reactions in small columns of functional polymers can also permit easy monitoring and shielding of radiochemical steps.

Keywords

Anion Exchange Resin Resin Column Phase Transfer Catalyst Target Water Acid Site Density 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • G. Keith Mulholland
    • 1
    • 2
  • Douglas M. Jewett
    • 1
  1. 1.Division of Nuclear MedicineUniversity of Michigan Medical SchoolAnn ArborUSA
  2. 2.Department of RadiologyIndiana University Medical SchoolIndianapolisUSA

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