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The Basics of Positron Emission Tomographic (PET) Imaging

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Abstract

Positron Emission Tomographic (PET) imaging is accomplished through the coincident detection of the 511 keV photons arising from the annihilation of positrons in material. PET imaging presents several advantages over other medical imaging techniques but also presents unique imaging challenges. PET detection efficiency is increased when compared to Single Photon Emission Computerized Tomographic (SPECT) techniques because electronic collimation of the detected photon removes the requirement for inefficient lead collimation. PET transaxial images have the best spatial and temporal resolution and quantitative accuracy of all nuclear medicine imaging modalities. Current manufacturers of PET instrumentation have optimized spatial resolution to near the limits imposed by the physics of positron flight and annihilation. Absolute quantitation is achieved using the fact that the total path length traveled by both annihilation photons is a constant regardless of the origin of the annihilation. This allows precise attenuation correction without iteration. The availability of biologically relevant tracers enables PET users to quantify in vivo physiological parameters through the application of mathematical models to static or a series of dynamic images. The desirability of absolute activity quantification and accurate parametric physiological images increases the importance of camera performance and image quality for PET.

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Authors and Affiliations

  1. School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332-0405, USA

    K. J. Kearfott

  2. Department of Radiology, Emory University School of Medicine, Atlanta, GA, 30322, USA

    J. R. Votaw

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  1. Health Science Center, The University of Texas, Houston, Texas, USA

    Ali M. Emran

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Kearfott, K.J., Votaw, J.R. (1995). The Basics of Positron Emission Tomographic (PET) Imaging. In: Emran, A.M. (eds) Chemists’ Views of Imaging Centers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9670-4_2

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