Lipocalycins Associated with Mammalian Pheromones

  • Alan G. Singer
  • Foteos Macrides


The female golden hamster produces a substance that is emitted in vaginal discharge around the time of estrus and stimulates sexual behavior in male hamsters. This pheromone may be demonstrated in a bioassay using an anesthetized male as a surrogate female, which is placed in the cage of a normal male (Macrides et al., 1984a). If estrous vaginal discharge containing the pheromone is applied to the hindquarters of the surrogate female, a normal male will typically make several intromission attempts consisting of distinct bouts of pelvic thrusting directed at the surrogate female. The number of these bouts can be used as a measure of the activity of the pheromone in vaginal discharge, as demonstrated by a dose-response relation (Macrides et al., 1984b).


Bank Vole Vaginal Discharge High Molecular Weight Fraction Vomeronasal Organ Major Urinary Protein 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Alan G. Singer
    • 1
  • Foteos Macrides
    • 2
  1. 1.Monell Chemical Senses CenterPhiladelphiaUSA
  2. 2.Worcester Foundation for Experimental BiologyShrewsburyUSA

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