Lipids and Colonic Carcinogenesis: Fact or Artefact?

  • Myriam Wilpart
  • Marcel Roberfroid


Life style and dietary habits play an important role in the causation and development of a number of major human cancers1. This conclusion is partly supported by evidence from epidemiological and laboratory animal studies. Investigators have attempted to study the mechanisms by which diet may influence carcinogenesis and to examine the ability of nutrients, food components or non-nutritive food additive components to enhance or to inhibit carcinogenesis. Cancer of the colon is one of the most common tumors observed in the affluent western populations2 for which the relationship between epidemiological and laboratory findings and an overall assessment of the influence of diet on carcinogenesis is not straight forward.


Colonic Carcinogenesis Positive Modulate Effect Major Human Cancers1 Experimental Colon Carcinogenesis Large Bowel Carcinogenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    B. S. Reddy, Nutritional aspects of colon cancer, in: “Progress in Food and Nutrition Science”, B. S. Reddy and L. A. Cohen, eds., Pergamon Press Ltd (USA), vol. 9 (1986).Google Scholar
  2. 2.
    D. M. Jensen, Colon cancer epidemiology, in: “Experimental Colon Carcinogenesis”, H. Autrup and G. M. Williams, eds., CRC Press, Boca Raton (1983).Google Scholar
  3. 3.
    M. B. Roberfroid, From normal cell to cancer an overview introducing the concept of modulation of carcinogenesis, in: “Concepts and Theories in Carcinogenesis”, A. P. Maskens, P. Ebbesen, and A. Burny, eds., Elsevier Amsterdam (1986).Google Scholar
  4. 4.
    A. W. Bull, B. K. Soullier, P. S. Wilson, M. T. Hayden and N. D. Nigro, Promotion of azoxymethane-induced intestinal cancer by high fat diet in rats, Cancer Res. 39:4956 (1979).PubMedGoogle Scholar
  5. 5.
    K. M. Nauss, M. Lockniskar and P. M. Newberne, Effects of alterations in the quality and quantity of dietary fat on 1,2-dimethylhydrazineinduced colon tumorigenesis in rats, Cancer Res. 43:4083 (1983).PubMedGoogle Scholar
  6. 6.
    M. Wilpart, Dietary fats and fiber and experimental colon carcinogenesis: a critical review of published evidences, in: “Causation and Prevention of Colorectal Cancer”, J. Faivre and M. J Hill, eds., Elsevier, Amsterdam (1987).Google Scholar
  7. 7.
    S. A. Broitman, J. Vitale, E. Varrousek-Jakula and L. S. Gottlich, Polyunsaturated fat: cholesterol and large bowel tumorigenesis, Cancer 40:2455 (1977).PubMedCrossRefGoogle Scholar
  8. 8.
    K. M. Nauss, M. Lockniskar, D. Sondergaard and P. M. Newberne, Lack of effect of dietary fat on N-nitrosomethylurea induced colon tumorigenesis in rats, Carcinogenesis 5:255 (1984).PubMedCrossRefGoogle Scholar
  9. 9.
    K. M. Watanabe, B. S. Reddy, C. Q. Wong and J. H. Weisburger, Effect of undegraded carrageenan on colon carcinogenesis in F 344 rats treated with azoxymethane or methylnitrosourea, Cancer Res. 38:4427 (1978).PubMedGoogle Scholar
  10. 10.
    B. S. Reddy, Dietary fat and cancer: specific action or caloric effect, J. Nutr. 116:1132 (1986).PubMedGoogle Scholar
  11. 11.
    N. D. Nigro, D. V. Singh, R. L. Campbell and M. S. Pack, Effects of dietary fat on intestinal tumour formation by azoxymethane in rats, J. Natl. Cancer Inst. 54:439 (1972).Google Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Myriam Wilpart
    • 1
  • Marcel Roberfroid
    • 1
  1. 1.Laboratoire de Biochimie Toxicologique et CancérologiqueU.C.L. 73.69BrusselsBelgium

Personalised recommendations