Modifying Influence of Fasting on DNA Synthesis, Cholesterol Metabolism and HMP Shunt Enzymes in Liver Hyperplasia Induced by Lead Nitrate
Previous studies by Columbano et al.1 have shown that lead nitrate when injected intravenously as a single dose to rats, induces an hyperplastic response in the liver as indicated by an increased DNA synthesis and by an enhanced mitotic index. Liver hyperplasia was accompanied by a stimulation of cholesterol synthesis and hexose-monophosphate (HMP) shunt enzymes2.
KeywordsPyruvate Kinase Cholesterol Synthesis Lead Nitrate Mevalonic Acid Pyruvate Kinase Activity
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