Modifying Influence of Fasting on DNA Synthesis, Cholesterol Metabolism and HMP Shunt Enzymes in Liver Hyperplasia Induced by Lead Nitrate

  • Sandra Dessì
  • Barbara Batetta
  • Donatella Pulisci
  • Annalisa Carrucciu
  • Marina Armeni
  • Maria F. Mulas
  • Paolo Pani

Abstract

Previous studies by Columbano et al.1 have shown that lead nitrate when injected intravenously as a single dose to rats, induces an hyperplastic response in the liver as indicated by an increased DNA synthesis and by an enhanced mitotic index. Liver hyperplasia was accompanied by a stimulation of cholesterol synthesis and hexose-monophosphate (HMP) shunt enzymes2.

Keywords

Pyruvate Kinase Cholesterol Synthesis Lead Nitrate Mevalonic Acid Pyruvate Kinase Activity 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Sandra Dessì
    • 1
  • Barbara Batetta
    • 1
  • Donatella Pulisci
    • 1
  • Annalisa Carrucciu
    • 1
  • Marina Armeni
    • 1
  • Maria F. Mulas
    • 1
  • Paolo Pani
    • 1
  1. 1.Istituto di Farmacologia e Patologia BiochimicaCagliariItaly

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