Regulation of S-Adenosyl-L-Methionine Decarboxylase in Normal and Regenerating Rat Liver by Adenosine-Containing Molecules

  • Giuseppe Scalabrino
  • Maria Elena Ferioli
  • Rossella Candiani


The pathway for polyamine biosynthesis in its entirety thought to play a pivotal role in the regulation of the proliferation of eukaryotic cells, simultaneously provides the cells with two types of factors that regulate the growth and the differentiation of mammalian cells in opposite directions. These are the polyamines, which stimulate cell growth and differentiation, and the sulphur-containing purine nucleoside 5′-deoxy-5′methylthioadenosine (MTA), which strongly inhibits growth and differentiation of mammalian cells1–5. Therefore, the study of the key points in the polyamine biosynthetic pathway seems to be of paramount importance for better understanding the mechanisms regulating the proliferation of eukaryotic cells.


Partial Hepatectomy Polyamine Biosynthesis Stimulate Cell Growth Dixon Plot Methionine Adenosyltransferase 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Giuseppe Scalabrino
    • 1
  • Maria Elena Ferioli
    • 1
  • Rossella Candiani
    • 1
  1. 1.Institute of General Pathology and C.N.R. Centre for Research in Cell PathologyUniversity of MilanMilanoItaly

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