Nuclear Alterations in Liver Carcinogenesis: The Role of Non-Polyploidizing Growth

  • Per O. Seglen
  • Per E. Schwarze
  • Gunnar Saeter


Polyploidization is a characteristic and dominant aspect of rat liver growth. As the animal matures, an increasing number of proliferating diploid hepatocytes undergo nuclear mitosis without cell division, resulting in the formation of tetraploid cells with two diploid nuclei. In the next cell cycle these binucleated cells form a single mitotic spindle and divide, yielding mononucleated tetraploid progeny. The latter may in turn undergo ordinary cell division, probably several times, or take one or two further steps along the polyploidization pathway, generating first binucleated, then mononucleated octoploid cells1,2.


Partial Hepatectomy Liver Carcinogenesis Liver Growth Absolute Cell Number Ploidy Class 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Per O. Seglen
    • 1
  • Per E. Schwarze
    • 1
  • Gunnar Saeter
    • 1
  1. 1.Department of Tissue Culture, Institute for Cancer ResearchThe Norwegian Radium Hospital MontebelloOslo 3Norway

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