S-Adenosylmethionine Antipromotion and Antiprogression Effect in Hepatocarcinogenesis. Its Association with Inhibition of DNA Methylation and Gene Expression

  • Francesco Feo
  • Renato Garcea
  • Lucia Daino
  • Rosa Pascale
  • Serenella Frassetto
  • Patrizia Cozzolino
  • Maria G. Vannini
  • Maria E. Ruggiu
  • Marilena Simile
  • Marco Puddu


The identification of several steps in the carcinogenic process, has permitted a new approach in the prevention of cancer development. It is conceivable that interference with one or more of the recognizable steps leads to the breakdown of the carcinogenic process. In recent years some attempts to interfere with carcinogenic promotion, at different levels, have been made using retinoids1,2, 1α, 25-dihydroxyvitamin D3, a hormonally active metabolite of vitamin D3, antioxidants4,5, α-difluoromethylornithine6,7, putrescine8, indomethacin9, protease inhibitors10, inhibitors of arachidonic acid metabolism11, protein kinase C inhibitors12, dehydroepiandrosterone and some related hormones13–16, and S-adenosylmethionine17–21 (SAM).


Chemical Carcinogenesis Polyamine Synthesis Great Fall Control Cell Death Neoplastic Nodule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Francesco Feo
    • 1
  • Renato Garcea
    • 1
  • Lucia Daino
    • 1
  • Rosa Pascale
    • 1
  • Serenella Frassetto
    • 1
  • Patrizia Cozzolino
    • 1
  • Maria G. Vannini
    • 1
  • Maria E. Ruggiu
    • 1
  • Marilena Simile
    • 1
  • Marco Puddu
    • 1
  1. 1.Istituto di Patologia GeneraleUniversità di SassariSassariItaly

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