Additive Effect of Low-Dose Diethylnitrosamine on the Initiation of Liver Carcinogenesis in Rats

  • Masahiro Tsutsumi
  • Seiichi Takahashi
  • Dai Nakae
  • Kazumi Shiraiwa
  • Tetsuo Kinugasa
  • Kenji Kamino
  • Ayumi Denda
  • Yoichi Konishi


Simultaneous or exposure to low-dose carcinogens existing in the environment is an important causal factor in human carcinogenesis. It is gener- ally accepted that carcinogenesis is a multi-step process consisting of two qualitatively different stages, initiation and promotion1. Initiation is a transient “flash” phenomenon involving exposure to a carcinogen and may occur frequently in humans.


Partial Hepatectomy Experimental Regimen Liver Carcinogenesis Experimental Schedule Important Causal Factor 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Masahiro Tsutsumi
    • 1
  • Seiichi Takahashi
    • 1
  • Dai Nakae
    • 1
  • Kazumi Shiraiwa
    • 1
  • Tetsuo Kinugasa
    • 1
  • Kenji Kamino
    • 2
  • Ayumi Denda
    • 1
  • Yoichi Konishi
    • 1
  1. 1.Department of Oncological PathologyCancer Center, Nara Medical CollegeKashihara, Nara 634Japan
  2. 2.Institute of PathologyUniversity of DüsseldorfDüsseldorfGerman

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