Cell Death by Apoptosis in Normal, Preneoplastic and Neoplastic Tissue

  • Rolf Schulte-Hermann
  • Wilfried Bursch
  • Lazlo Fesus
  • Bettina Kraupp


Cells of hiher organisms can die through different causes and under different circumstances which can be classified broadly into at least 3 different categories:
  1. 1.

    Massive tissue injury such as after hypoxia or after CCl4 in the liver. Some authors restrict use of the term necrosis to cell death occurring after massive tissue damage1,2.

  2. 2.

    Terminal differentiation of tissues such as skin, intestine or blood cells.

  3. 3.

    Regression of organs, elimination of excessive cells, cell turnover in healthy tissues. During development certain organs regress such as the Mullerian duct in the male embryo. In the adult organism atrophy or removal of hyperplasia may occur in hormone-dependent organs. The type of cell death involved has recently been designated “apoptosis”1,3–8. It is conceived as a genetically encoded cellular suicide program that can be activated in situations where cell elimination appears physiologically advantageous or even necessary. Examples of physiological states in which apoptosis is believed to occur are given in Table 1. It appears that apoptosis is a widespread phenomenon which has been observed in a variety of species throughout the animal kingdom and in various organs during developmental stages and adulthood.



Apoptotic Body Cyproterone Acetate Mullerian Duct Control Cell Death Preneoplastic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Rolf Schulte-Hermann
    • 1
  • Wilfried Bursch
    • 1
  • Lazlo Fesus
    • 1
    • 2
  • Bettina Kraupp
    • 1
  1. 1.Institute of Tumorbiology-Cancer ResearchUniversity of ViennaViennaAustria
  2. 2.Department of BiochemistryUniversity Medical School of DebrecenDebrecenHungary

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