Mechanism of Enyzmatic Phosphotriester Hydrolysis

  • Steven R. Caldwell
  • Frank M. Raushel
Part of the Industry-University Cooperative Chemistry Program Symposia book series (IUCC)


There are numerous reports from various sources of crude enzyme systems that appear to be capable of hydrolyzing organophosphotriesters (1–8). Unfortunately, none of these enzymes has ever thoroughly been characterized or purified to homogeneity. However, we have recently succeeded in the first isolation and characterization of a phosphotriesterase from Pseudomonas diminuta and this enzyme is the focus of this presentation.


Zinc Atom Triose Phosphate Isomerase Organophosphate Pesticide Phosphorus Center Diethyl Phosphate 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Steven R. Caldwell
    • 1
  • Frank M. Raushel
    • 1
  1. 1.Departments of Chemistry and Biochemistry & BiophysicsTexas A & M UniversityCollege StationUSA

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