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An Enzyme-Targeted Herbicide Design Program Based on EPSP Synthase: Chemical Mechanism and Glyphosate Inhibition Studies

  • Chapter
Chemical Aspects of Enzyme Biotechnology

Abstract

The herbicide markets of the late 1990’s and beyond will demand high performance products with stringent environmental acceptability requirements. We have initiated a multi-disciplinary herbicide discovery program directed toward the inhibition of key plant enzymes as one approach to meet these challenges. Plants contain a variety of biosynthetic pathways which are essential for their growth. Effective, plant-specific enzyme inhibitors offer the opportunity to satisfy the herbicide performance needs of the marketplace while exhibiting favorably low mammalian toxicity properties.1 Our enzyme-targeted research effort systematically integrates mechanistic biochemistry, molecular biology, modeling, inhibitor recognition, and structural biology information with organic synthesis through a series of collaborations within and outside Monsanto. A thorough understanding of the chemical mechanism for a particular enzyme target is an essential first step for the design of potent inhibitors.

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Author information

Authors and Affiliations

  1. Technology Division, Monsanto Agricultural Company, A Unit of Monsanto Company, 800 N. Lindbergh Blvd., St. Louis, MO, 63167, USA

    James A. Sikorski, Darryl G. Cleary, Michael J. Miller, Paul D. Pansegrau, Joel E. Ream & R. Douglas Sammons

  2. Departments of Molecular & Cell Biology and Chemistry, The Pennsylvania State Univ., 301 Althouse Laboratory, University Park, PA, 16802, USA

    Karen S. Anderson & Kenneth A. Johnson

Authors
  1. James A. Sikorski
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  2. Karen S. Anderson
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  3. Darryl G. Cleary
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  4. Michael J. Miller
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  5. Paul D. Pansegrau
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  6. Joel E. Ream
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  7. R. Douglas Sammons
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  8. Kenneth A. Johnson
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Editor information

Editors and Affiliations

  1. Texas A&M University, College Station, Texas, USA

    Thomas O. Baldwin , Frank M. Raushel  & A. Ian Scott ,  & 

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© 1990 Springer Science+Business Media New York

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Sikorski, J.A. et al. (1990). An Enzyme-Targeted Herbicide Design Program Based on EPSP Synthase: Chemical Mechanism and Glyphosate Inhibition Studies. In: Baldwin, T.O., Raushel, F.M., Scott, A.I. (eds) Chemical Aspects of Enzyme Biotechnology. Industry-University Cooperative Chemistry Program Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9637-7_3

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  • DOI: https://doi.org/10.1007/978-1-4757-9637-7_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9639-1

  • Online ISBN: 978-1-4757-9637-7

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