An Enzyme-Targeted Herbicide Design Program Based on EPSP Synthase: Chemical Mechanism and Glyphosate Inhibition Studies

  • James A. Sikorski
  • Karen S. Anderson
  • Darryl G. Cleary
  • Michael J. Miller
  • Paul D. Pansegrau
  • Joel E. Ream
  • R. Douglas Sammons
  • Kenneth A. Johnson
Part of the Industry-University Cooperative Chemistry Program Symposia book series (IUCC)


The herbicide markets of the late 1990’s and beyond will demand high performance products with stringent environmental acceptability requirements. We have initiated a multi-disciplinary herbicide discovery program directed toward the inhibition of key plant enzymes as one approach to meet these challenges. Plants contain a variety of biosynthetic pathways which are essential for their growth. Effective, plant-specific enzyme inhibitors offer the opportunity to satisfy the herbicide performance needs of the marketplace while exhibiting favorably low mammalian toxicity properties.1 Our enzyme-targeted research effort systematically integrates mechanistic biochemistry, molecular biology, modeling, inhibitor recognition, and structural biology information with organic synthesis through a series of collaborations within and outside Monsanto. A thorough understanding of the chemical mechanism for a particular enzyme target is an essential first step for the design of potent inhibitors.


Ternary Complex Vinyl Ether Internal Equilibrium Tetrahedral Intermediate Minor Structural Change 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • James A. Sikorski
    • 1
  • Karen S. Anderson
    • 2
  • Darryl G. Cleary
    • 1
  • Michael J. Miller
    • 1
  • Paul D. Pansegrau
    • 1
  • Joel E. Ream
    • 1
  • R. Douglas Sammons
    • 1
  • Kenneth A. Johnson
    • 2
  1. 1.Technology DivisionMonsanto Agricultural Company, A Unit of Monsanto CompanySt. LouisUSA
  2. 2.Departments of Molecular & Cell Biology and ChemistryThe Pennsylvania State Univ.University ParkUSA

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