On the Mechanism of Action of Vitamin B12: A Non-Free Radical Model for the Methylmalonyl-CoA — Succinyl-CoA Rearrangement
Part of the Industry-University Cooperative Chemistry Program Symposia book series (IUCC)
Vitamin B12, in its coenzyme form, plays an essential role in mammalian metabolism where it serves as an obligatory cofactor for methylmalonyl-CoA mutase, which mediates the carbon skeleton rearrangement of methylmalonyl-CoA to succinyl-CoA1 (eq 1). The purpose of this enzymic rearrangement is to conduct propionate, by way of methylmalonate and succinate, to the Krebs cycle and the main stream of biochemical metabolism.
KeywordsCyclic Product Relative Peak Area Observe Rate Constant Product Succinate Methyl Malonyl
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References and Notes
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