Abstract
Vitamin B12, in its coenzyme form, plays an essential role in mammalian metabolism where it serves as an obligatory cofactor for methylmalonyl-CoA mutase, which mediates the carbon skeleton rearrangement of methylmalonyl-CoA to succinyl-CoA1 (eq 1). The purpose of this enzymic rearrangement
is to conduct propionate, by way of methylmalonate and succinate, to the Krebs cycle and the main stream of biochemical metabolism.
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References and Notes
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This research was generously supported by the National Institute for General Medical Sciences of the National Institutes of Health under Grant GM 19906.
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Dowd, P., Choi, G., Wilk, B., Choi, SC., Zhang, S., Shepherd, R.E. (1990). On the Mechanism of Action of Vitamin B12: A Non-Free Radical Model for the Methylmalonyl-CoA — Succinyl-CoA Rearrangement. In: Baldwin, T.O., Raushel, F.M., Scott, A.I. (eds) Chemical Aspects of Enzyme Biotechnology. Industry-University Cooperative Chemistry Program Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9637-7_19
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