Stereoselective Synthesis of Biologically and Pharmacologically Important Chemicals with Microbial Enzymes
In recent years, the most significant development in the field of synthetic chemistry has been the application of biological systems to chemical reactions. Reactions catalyzed by enzymes or enzyme systems display far greater specificities than more conventional forms of organic reactions, and of all the reactions available, some of which have been shown to be useful for synthetic or biotechnological applications.
KeywordsOptical Purity Butyl Acetate Candida Parapsilosis Glucose Dehydrogenase Molar Yield
Unable to display preview. Download preview PDF.
- 2.H. Yamada and S. Shimizu, Biotechnology — microbial conversion, in: “Ullman’s Encyclopedia of Industrial Chemistry,” Vol. A4, VCH Verlagsgesellschaft, Weinheim, pp. 150–170 (1985).Google Scholar
- 4.H. Yamada and S. Shimizu, Microbial enzymes as catalysts for synthesis of biologically useful compounds in: “Biocatalysts in Organic Synthesis,” J. Tramper, H. C. van der Pals and P. Linko, eds., Elsevier, Amsterdam, pp. 19–37 (1985).Google Scholar
- 5.S. Shimizu and H. Yamada, Coenzymes, in: “Biotechnology,” Vol. 4, H.-J. Rehm and G. Reed, eds., VCH Verlagsgesellschaft, Weinheim, pp. 159–184 (1986).Google Scholar
- 12.H. Hata, S. Shimizu, S. Hattori and H. Yamada, Stereoselective reduction of diketones by a novel carbonyl reductase from Candida parapsilosis, J. Org. Chem. in press.Google Scholar
- 16.K. Sakamoto, S. Kita, T. Morikawa, S. Shimizu, and H. Yamada, Preparation of ethyl 2′-ketopantothenate, Japanese patent application Hl-45407 (1989).Google Scholar
- 17.S. Shimizu, K. Sakamoto and H, Yamada, Studies on the enzymatic hydrolysis of pantothenate esters (in Japanese) Nippon Nogeikagaku Kaishi 62:283 (1987).Google Scholar
- 18.M. Kataoka, S. Shimizu, Y. Doi and H. Yamada, Stereoselective reduction of ethyl 2′-ketopantothenate to ethyl D-(+)-pantothenate with microbial cells as a catalyst, Appl. Environ. Microbiol. submitted.Google Scholar
- 19.M. Kataoka, S. Shimizu, Y. Doi, K. Sakamoto and H. Yamada, Microbial production of chiral pantothenonitrile through stereospecific reduction of 2′-ketopantothenonitrile, Biotechnol. Lett, submitted.Google Scholar
- 23.M. Seim and H-P. Kleber, Synthesis L-(−)-carnitine by hydration of crotonobetaine by entrobacteria, Appl. Microbiol. Biotechnol. 27:538 (1988).Google Scholar
- 26.H. Yamada, S. Shimizu, M. Kataoka and T. Miyoshi, A novel NADPH-dependent aldehyde reductase, catalyzing asymmetric reduction of β-keto acid esters, from Sporobolomyces salmonicolor, purification and characterization, FEMS Microbiol. Lett. in press.Google Scholar
- 27.S. Shimizu and H. Yamada, Stereospecific reduction of 3-keto acid esters by a novel aldehyde reductase of Sporobolomyces salmonicolor in a water-organic solvent two phasic system, Ann. N. Y. Acad. Sci, in press.Google Scholar
- 28.S. Shimizu, M. Kataoka, M. Katoh, T. Morikawa, T. Miyoshi and H. Yamada, Stereospecific reduction of ethyl 4-chloro-3-oxobutanoate by a microbial aldehyde reductase in an organic solvent-water two phasic system, Appl. Environ. Microbiol. submitted.Google Scholar