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Chaos in a System of Interacting Nephrons

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Book cover Chaos in Biological Systems

Part of the book series: NATO ASI Series ((NSSA,volume 138))

Abstract

Urine is formed from blood by a process of filtration followed by selective reabsorption and secretion. The basic functional unit is the nephron of which there are about 30,000 in a rat kidney (1 million in a human kidney).

Recent experimental results have revealed an oscillatory behaviour of the proximal intratubular pressure in rat nephrons with a typical period of 20–30 sec. The oscillations are assumed to arise from temporal self-organisation in the glomerular filtration of the individual nephron. While for normal rats these oscillations have a well-defined frequency and amplitude, highly irregular oscillations are observed for spontaneously hypertensive rats.

We present some simulation results from models of non-interacting as well as coupled nephrons and compare these with results from analysis of experimental data.

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References

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Author information

Authors and Affiliations

  1. Physics Laboratory III, Technical University of Denmark, DK-2800, Lyngby, Denmark

    Klaus Skovbo Jensen, Erik Mosekilde & Dan Rene Rasmussen

  2. Institute for Experimental Medicine, University of Copenhagen, DK-2100, Copenhagen, Denmark

    Niels-Henrik Holstein-Rathlou & Paul P. Leyssac

Authors
  1. Klaus Skovbo Jensen
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  2. Niels-Henrik Holstein-Rathlou
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  3. Paul P. Leyssac
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  4. Erik Mosekilde
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  5. Dan Rene Rasmussen
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Editor information

Editors and Affiliations

  1. Odense University, Odense, Denmark

    H. Degn  & L. F. Olsen  & 

  2. The University of Leeds, Leeds, UK

    A. V. Holden

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© 1987 Springer Science+Business Media New York

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Jensen, K.S., Holstein-Rathlou, NH., Leyssac, P.P., Mosekilde, E., Rasmussen, D.R. (1987). Chaos in a System of Interacting Nephrons. In: Degn, H., Holden, A.V., Olsen, L.F. (eds) Chaos in Biological Systems. NATO ASI Series, vol 138. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9631-5_5

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  • DOI: https://doi.org/10.1007/978-1-4757-9631-5_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9633-9

  • Online ISBN: 978-1-4757-9631-5

  • eBook Packages: Springer Book Archive

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