Chaos in a System of Interacting Nephrons

  • Klaus Skovbo Jensen
  • Niels-Henrik Holstein-Rathlou
  • Paul P. Leyssac
  • Erik Mosekilde
  • Dan Rene Rasmussen
Part of the NATO ASI Series book series (NSSA, volume 138)

Abstract

Urine is formed from blood by a process of filtration followed by selective reabsorption and secretion. The basic functional unit is the nephron of which there are about 30,000 in a rat kidney (1 million in a human kidney).

Recent experimental results have revealed an oscillatory behaviour of the proximal intratubular pressure in rat nephrons with a typical period of 20–30 sec. The oscillations are assumed to arise from temporal self-organisation in the glomerular filtration of the individual nephron. While for normal rats these oscillations have a well-defined frequency and amplitude, highly irregular oscillations are observed for spontaneously hypertensive rats.

We present some simulation results from models of non-interacting as well as coupled nephrons and compare these with results from analysis of experimental data.

Keywords

Phase Portrait Correlation Dimension Pressure Oscillation Afferent Arteriole Irregular Oscillation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Klaus Skovbo Jensen
    • 1
  • Niels-Henrik Holstein-Rathlou
    • 2
  • Paul P. Leyssac
    • 2
  • Erik Mosekilde
    • 1
  • Dan Rene Rasmussen
    • 1
  1. 1.Physics Laboratory IIITechnical University of DenmarkLyngbyDenmark
  2. 2.Institute for Experimental MedicineUniversity of CopenhagenCopenhagenDenmark

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