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Neurotransmitter Receptors in Developing Barrel Cortex

  • Chapter
The Barrel Cortex of Rodents

Part of the book series: Cerebral Cortex ((CECO,volume 11))

Abstract

The whisker barrel cortex can serve as a useful model for examining the role of neurotransmitter receptors in brain development. Most of the synapses in neocortex of laboratory rats and mice are formed during the first 3–4 postnatal weeks (Wolff, 1978). During this period, synaptic remodeling takes place as thalamocortical, callosal, and intrinsic connections are sharpened and refined (Wise and Jones, 1978; O’Leary et al., 1981; Greenough and Chang, 1988). The developmental blueprint can be readily modified by neonatal whisker deafferentation, and the consequences can be well localized because of the one-to-one correspondence between major vibrissae and whisker barrels. Moreover, its location on the dorsal surface of the brain makes barrel cortex accessible to direct pharmacological manipulations.

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  1. Department of Biological Sciences, University of North Texas, Denton, Texas, 76203, USA

    Jannon L. Fuchs

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  1. California College of Medicine, University of California, Irvine, Irvine, California, USA

    Edward G. Jones

  2. Duke University, Durham, North Carolina, USA

    Irving T. Diamond

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Fuchs, J.L. (1995). Neurotransmitter Receptors in Developing Barrel Cortex. In: Jones, E.G., Diamond, I.T. (eds) The Barrel Cortex of Rodents. Cerebral Cortex, vol 11. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9616-2_9

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