Neurotransmitter Receptors in Developing Barrel Cortex

  • Jannon L. Fuchs
Part of the Cerebral Cortex book series (CECO, volume 11)


The whisker barrel cortex can serve as a useful model for examining the role of neurotransmitter receptors in brain development. Most of the synapses in neocortex of laboratory rats and mice are formed during the first 3–4 postnatal weeks (Wolff, 1978). During this period, synaptic remodeling takes place as thalamocortical, callosal, and intrinsic connections are sharpened and refined (Wise and Jones, 1978; O’Leary et al., 1981; Greenough and Chang, 1988). The developmental blueprint can be readily modified by neonatal whisker deafferentation, and the consequences can be well localized because of the one-to-one correspondence between major vibrissae and whisker barrels. Moreover, its location on the dorsal surface of the brain makes barrel cortex accessible to direct pharmacological manipulations.


Somatosensory Cortex Neurotransmitter Receptor Cortical Plate Postnatal Development Transmitter Receptor 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Jannon L. Fuchs
    • 1
  1. 1.Department of Biological SciencesUniversity of North TexasDentonUSA

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