Antisense-Mediated Inhibition of Aminopeptidase N (CD13) Markedly Decreases Growth Rates of Hematopoietic Tumour Cells

  • T. Wex
  • U. Lendeckel
  • D. Reinhold
  • T. Kähne
  • M. Arndt
  • K. Frank
  • S. Ansorge
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 421)

Abstract

There are several reports describing neutral aminopeptidase activities expressed in immune cells1–7. One of the best studied members of these enzymes is the Zn-dependent aminopeptidase N (CD13, E.C.3.4.11.2, APN) Within the hematopoietic system the expression of this leukocyte surface antigen was thought to be restricted to myelomonocytic cells 1,8,9. During recent years, it has been proven that lymphoid cells contain APN-mRNA and express corresponding enzymatic activity, too 2–4,7,10,11. These cells contain very low amounts of CD13 only, and therefore, are predominantly CD13-negative1,9,12,13. Recently, different groups have been provided conclusive evidence that CD13 is strongly induced during processes such as T cell activation or inflammation, suggesting that this antigen may well be involved in the regulation of proliferation and differentiation processes3,12,14–15.

Keywords

U937 Cell Aminopeptidase Activity Human Renal Cell Carcinoma Human Renal Cell Carcinoma Cell Antisense Transfectants 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • T. Wex
    • 1
  • U. Lendeckel
    • 1
  • D. Reinhold
    • 1
  • T. Kähne
    • 1
  • M. Arndt
    • 1
  • K. Frank
    • 1
  • S. Ansorge
    • 1
  1. 1.Institute of Experimental Internal Medicine Center of Internal MedicineOtto-von-Guericke University MagdeburgMagdeburgGermany

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