Matrix Metalloproteinases in Experimental Autoimmune Encephalomyelitis

  • Bernd C. Kieseier
  • Hans-Peter Hartung
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 421)


The matrix metalloproteinases (MMPs) belong to a large subgroup of Zn2+-dependent neutral endoproteinases, which includes the collagenases, gelatinases, and the stromelysins. The number of MMPs known is growing rapidly and they all share at least four common features [1]: (a) they all display proteolytic activity, (b) they are functionally active in the extracellular space, and on the eDNA level (c) protein sequences for the cysteine switch mechanism (PRCGxPD), which is important for their activation, and (d) protein sequences for the binding of catalytic zinc (HExGHxxGxxHS/T) can be found.


Multiple Sclerosis Experimental Autoimmune Encephalomyelitis Proteolytic Activity Myelin Basic Protein Neuroinflammatory Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Bernd C. Kieseier
    • 1
  • Hans-Peter Hartung
    • 1
  1. 1.Department of Neurology Neuroimmunology Branch and Clinical Research Group for Multiple SclerosisJulius-Maximilians-UniversitätWürzburgGermany

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