Dipeptidyl Peptidase IV (CD26) and Alzheimer Amyloid Protein Precursor (APP) in Polymyositis

  • Walter Schubert
  • Karin Agha-Amiri
  • Oleg Mayboroda
  • Christoph Rethfeldt
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 421)


There are two major types of immune cell infiltration in human neuromuscular disorders: the polymyositis/inclusion body (PM/IBM) and the dermatomyositis (DM) type. In the PM/IBM type of immune cell invasion, T lymphocytes accumulating within the endomysium (space between muscle fibers) penetrate the basal lamina of intact muscle fibers (endomysial tube) and continuously displace and compress the muscle fiber plasma membrane. In the DM type of infiltration T and B lymphocytes accumulate in the perimysium and around blood vessels.


Invasive Front Dipeptidyl Peptidase Immune Cell Infiltration Human Peripheral Blood Leukocyte ALZHEIMER Amyloid Protein Precursor 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Walter Schubert
    • 1
  • Karin Agha-Amiri
    • 1
  • Oleg Mayboroda
    • 1
  • Christoph Rethfeldt
    • 1
  1. 1.Institute of Medical Neurobiology Neuroimmunology and Molecular Pattern Recognition Research Group, Medical FacultyOtto-von-Guericke-University of MagdeburgMagdeburgGermany

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