Abstract
There are two major types of immune cell infiltration in human neuromuscular disorders: the polymyositis/inclusion body (PM/IBM) and the dermatomyositis (DM) type. In the PM/IBM type of immune cell invasion, T lymphocytes accumulating within the endomysium (space between muscle fibers) penetrate the basal lamina of intact muscle fibers (endomysial tube) and continuously displace and compress the muscle fiber plasma membrane. In the DM type of infiltration T and B lymphocytes accumulate in the perimysium and around blood vessels.
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Schubert, W., Agha-Amiri, K., Mayboroda, O., Rethfeldt, C. (1997). Dipeptidyl Peptidase IV (CD26) and Alzheimer Amyloid Protein Precursor (APP) in Polymyositis. In: Ansorge, S., Langner, J. (eds) Cellular Peptidases in Immune Functions and Diseases. Advances in Experimental Medicine and Biology, vol 421. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9613-1_36
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DOI: https://doi.org/10.1007/978-1-4757-9613-1_36
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