Expression of Cysteine Protease Inhibitors Stefin A, Stefin B, and Cystatin C in Human Lung Tumor Tissue

  • Eileen Ebert
  • Bernd Werle
  • Britta Jülke
  • Natasa Kopitar-Jerala
  • Janko Kos
  • Tamara Lah
  • Magnus Abrahamson
  • Eberhard Spiess
  • Werner Ebert
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 421)


In human lung tumor tissue specimen (n=73) concentrations of stefins A and B were found to be increased 2.0-fold (p<0.01) and 1.3-fold (p<0.01), respectively, as compared to matched normal tissue. Stefn A and B concentrations were higher in primary tumors than in secondary tumors, i.e. metastases from other organs to the lung (p<0.01; p<0.05, respectively). Cystatin C concentrations were rather low and did not differ between tumor and normal tissue. Both concentrations of stefins did not correlate with TNM stages. Stefin A was higher in squamous cell carcinoma than in adenocarcinoma (p<0.01), while stefin B did not show such a difference. At investigation of a relationship between survival probability of patients with primary tumors it was found that increased stefin B concentrations and total cysteine-protease-inhibitory activities but not stefin A concentrations were positively correlated with survival probability.

It is concluded that stefins A and B are major contributors to the cysteine protease inhibitory activity in primary lung tumors. Stefin B proved to be a prognostic factor, especially in squamous cell carcinoma.


Squamous Cell Carcinoma Cysteine Protease Lung Tumor Normal Lung Tissue Large Cell Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Eileen Ebert
    • 1
  • Bernd Werle
    • 1
  • Britta Jülke
    • 1
  • Natasa Kopitar-Jerala
    • 2
  • Janko Kos
    • 2
  • Tamara Lah
    • 3
  • Magnus Abrahamson
    • 4
  • Eberhard Spiess
    • 5
  • Werner Ebert
    • 1
    • 6
  1. 1.Thoraxklinik Heidelberg-RohrbachHeidelbergGermany
  2. 2.Department of Biochemistry and Molecular Biology Jamova 39 and Krka, p.o., R&D DivisionJozef Stefan InstituteLjubljanaSlovenia
  3. 3.National Institute of BiologyLjubljanaSlovenia
  4. 4.University Hospital Department of Clinical ChemistryUniversity of LundLundSweden
  5. 5.Biomedizinische Strukturforschung INF 280Deutsches KrebsforschungszentrumHeidelbergGermany
  6. 6.Thoraxklinik Heidelberg-RohrbachHeidelberg-RohrbachGermany

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