Aminopeptidase P

A Cell-Surface Antigen of Endothelial and Lymphoid Cells
  • Jürgen Lasch
  • Sylke Moschner
  • Regine Koelsch
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 421)


Many mammalian cell-surface proteins are linked posttranslationally to complex glycosyl phosphatidylinositol (GPI) anchors which associate these proteins with the outer leaflet of the plasma membrane (type V membrane proteins). At least 50 of such proteins are known today in mammals. GPI-proteins include complement regulatory factors 1, cell adhesion molecules 2, receptors of the Fc part of immunoglobulins 2, ADP-ribosyltransferases 3 and ectoenzymes 4, e.g. aminopeptidase P 5.6.7.. They have been found on a variety of cells including endothelial cells 8. They differ from peptide-anchored transmembrane proteins (type I – IV membrane proteins) in cell-surface distribution, lateral mobility and lipid environment 9.


Outer Leaflet Relative Light Unit Human Aortic Endothelial Cell Stratum Corneum Lipid Myeloid Cell Line 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Jürgen Lasch
    • 1
  • Sylke Moschner
    • 1
  • Regine Koelsch
    • 1
  1. 1.Institute of Physiological Chemistry Medical FacultyMartin-Luther-UniversityHalleGermany

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