Summary
The membrane-expressed HIV-1 envelope glycoprotein complex, gp120/gp41, has been shown to be responsible for the initiation of cell killing by apoptosis in CD4+ T cells. By using two experimental approaches we demonstrate that CD26, independent of its DPP IV activity, appears to be implicated in this function of the gp120/gp41 complex to initiate apoptosis.
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Jacotot, E., Callebaut, C., Blanco, J., Rivière, Y., Krust, B., Hovanessian, A.G. (1997). CD26 as a Positive Regulator of HIV Envelope-Glycoprotein Induced Apoptosis in CD4+ T Cells. In: Ansorge, S., Langner, J. (eds) Cellular Peptidases in Immune Functions and Diseases. Advances in Experimental Medicine and Biology, vol 421. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9613-1_27
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DOI: https://doi.org/10.1007/978-1-4757-9613-1_27
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