CD26 as a Positive Regulator of HIV Envelope-Glycoprotein Induced Apoptosis in CD4+ T Cells

  • E. Jacotot
  • C. Callebaut
  • J. Blanco
  • Y. Rivière
  • B. Krust
  • A. G. Hovanessian
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 421)

Summary

The membrane-expressed HIV-1 envelope glycoprotein complex, gp120/gp41, has been shown to be responsible for the initiation of cell killing by apoptosis in CD4+ T cells. By using two experimental approaches we demonstrate that CD26, independent of its DPP IV activity, appears to be implicated in this function of the gp120/gp41 complex to initiate apoptosis.

Keywords

Human Immunodeficiency Virus Human Immunodeficiency Virus Infection Jurkat Cell Syncytium Formation Jurkat Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • E. Jacotot
    • 1
  • C. Callebaut
    • 1
  • J. Blanco
    • 1
  • Y. Rivière
    • 1
  • B. Krust
    • 1
  • A. G. Hovanessian
    • 1
  1. 1.Unité de Virologie et Immunologie Cellulaire, UA CNRS 1157Institut PasteurFrance

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