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CD26 as a Positive Regulator of HIV Envelope-Glycoprotein Induced Apoptosis in CD4+ T Cells

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Cellular Peptidases in Immune Functions and Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 421))

Summary

The membrane-expressed HIV-1 envelope glycoprotein complex, gp120/gp41, has been shown to be responsible for the initiation of cell killing by apoptosis in CD4+ T cells. By using two experimental approaches we demonstrate that CD26, independent of its DPP IV activity, appears to be implicated in this function of the gp120/gp41 complex to initiate apoptosis.

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Author information

Authors and Affiliations

  1. Unité de Virologie et Immunologie Cellulaire, UA CNRS 1157, Institut Pasteur, 28, rue du Dr. Roux, 75724, Paris cedex 15, France

    E. Jacotot, C. Callebaut, J. Blanco, Y. Rivière, B. Krust & A. G. Hovanessian

Authors
  1. E. Jacotot
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  2. C. Callebaut
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  3. J. Blanco
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  4. Y. Rivière
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  5. B. Krust
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  6. A. G. Hovanessian
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Editor information

Editors and Affiliations

  1. Institute of Experimental Internal Medicine, Otto von Guericke University, Magdeburg, Germany

    Siegfried Ansorge

  2. Institute of Medical Immunology, Martin Luther University, Halle, Germany

    Jürgen Langner

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© 1997 Springer Science+Business Media New York

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Jacotot, E., Callebaut, C., Blanco, J., Rivière, Y., Krust, B., Hovanessian, A.G. (1997). CD26 as a Positive Regulator of HIV Envelope-Glycoprotein Induced Apoptosis in CD4+ T Cells. In: Ansorge, S., Langner, J. (eds) Cellular Peptidases in Immune Functions and Diseases. Advances in Experimental Medicine and Biology, vol 421. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9613-1_27

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  • DOI: https://doi.org/10.1007/978-1-4757-9613-1_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9615-5

  • Online ISBN: 978-1-4757-9613-1

  • eBook Packages: Springer Book Archive

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