Abstract
T lymphocyte activation is controlled by the T cell antigen receptor-CD3 complex and a number of accessory molecules on the surface of lymphocytes which are triggered by special ligands outside of the cell. During the last years, there has been a considerable progress in the identification of these accessory structures and the mechanisms of their actions.
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References
Hopsu-Havu VK, Glenner GG (1966) A new peptide naphtylamidase hydrolyzing glycylprolyl-naphtylamide. Histochemistry 7: 197–201
Kenny AJ, Booth AG. George SG (1976) Dipeptidyl peptidase IV. a kidney brush border serine peptidase. Biochcm J 157:169–182
Stein H, Schwarting R, Niedobitek G (1989) Cluster report: CD26. In: Leukocyte Typing IV, Oxford Press, Oxford, pp 412–418
Matters T, Flad H-D, Feller AC, Heymann E, Ulmer AJ (1989) Anti-DPIV and anti-Tal but not IOT15 should be clustered in CDw26. In: Leukocyte Typing IV, edited by Knapp W, Dorken B, Gilks WR. Oxford Press, Oxford, pp 416
Ulmer AJ, Matters T, Feller AC, Heymann E, Flad HD (1990) CD26 antigen is a surface dipeptidyl peptidase IV (DPPIV) as characterized by monoclonal antibodies clone TII–19–4–7 and 4ELIC7. Scand.I Immunol 31: 429 – 435
Hegen M, Niedobitek G, Klein CE, Stein H, Fleischer B (1990) The T cell triggering molecule Tp103 is associated with dipeptidyl aminopeptidase IV activity. J Immunol 144: 2908–2914
Fleischer B (1995) Dipeptidyl peptidase IV (CD26) in metabolism and the immune response, R. G. Landes Company Austin, Texas, USA, pp 202
Schön E, Mansfeld HW, Demuth HU, Barth A, Ansorge S (1985) The dipeptidyl peptidase IV, a membrane enzyme involved in the proliferation of T lymphocytes. Biomed Biochim Acta 44 (2):K 9-K 15
Schön E, Born I, Demuth HU, Faust J, Neubert K, Steinmetzer T, Barth A, Ansorge S (1991) Dipeptidyl Peptidase IV in the immune system. Effects of specific inhibitors on activity of dipeptidyl peptidase IV and proliferation of human lymphocytes. Biol Chem Hoppe Seyler 372: 305–311
Bühling F, Kunz D, Reinhold D, Ulmer AJ, Ernst M, Flad HD, Ansorge S (1994) Expression and functional role of dipeptidyl peptidase IV (CD26) on human natural killer cells. Nat Immunity 13: 270–279
Bühling F, Junker U, Reinhold D, Neubert K, Jäger L, Ansorge S (1995) Functional role of CD26 on human B lymphocytes. Immunology Letters 45: 47–51
Reinhold D, Bank U, Bühling F, Kähne T, Kunz D, Faust J, Neubert K, Ansorge S (1994) Inhibitors of dipeptidyl peptidase 1V (DPIV, CD26) specifically suppress proliferation and modulate cytokine production of strongly CD26 expressing U937 cells. Immunobiology 192: 121–136
Kähne T, Reinhold D, Lendeckel U, Bühling F, Täger M, Faust J (1997) The effect of anti-CD26 antibodies on DNA synthesis and cytokine production (1L-2, IL- I O and IFN-y) depends on enzymatic activity of DPIV CD26. In: Leukocyte Typing VI, edited by Kishimoto T. Garland Publishing, Cambridge, in press
Kähne T, Kröning H, Thiel U, Ulmer AJ, Flad H-D, Ansorge S (1996) Alterations in structure and cellular localization of molecular forms of DPIV/CD26 during T cell activation. Cell Immunol 170: 63–70
Poppema S. Visser L (1996) Some CD26 reagents directly activate T cells. Tissue Antigens 48: 451 (Abstract)
Ansorge S, Bühling F, Hoffmann T, Kähne T, Neubert K, Reinhold D (1995) DPIV/CD26 on human lymphocytes: Functional roles in cell growth and cytokine regulation. In: Dipeptidyl peptidase IV (CD26) in metabolism and the immune response, edited by Fleischer B. Springer-Verlag, Heidelberg. Germany. pp 163–184
Hoffmann T, Faust J, Neubert K, Ansorge S (1993) Dipeptidyl peptidase IV (CD26) and Aminopcptidase N (CD13) catalyzed hydrolysis of cytokines and peptides with N-terminal cytokine sequences. FEES Letters 336,Nr.l: 61–64
Hoffmann T, Reinhold D, Kähne T, Faust J, Neubert K, Frank R, Ansorge S (1995) Inhibition of dipeptidyl peptidase IV ( DP IV) by anti-DP IV antibodies and non-substrate X-X-Pro-oligopeptides ascertained by capillary electrophoresis. J Chromatography 716: 355–362
Wrenger S, Reinhold D, Hoffmann T, Kraft M, Frank R. Faust J. Neubert K, Ansorge S (1996) The N-terminal X-X-Pro sequence of the HIV-1 Tat protein is important for the inhibition of dipeptidyl peptidase IV (DP IV/CD26) and the suppression of mitogen-induced proliferation of human T cells. FEBS Letters 383: 145–149
Reinhold D, Wrenger S, Bank U, Bühling F, Hoffmann T, Neubert K. Kraft M, Frank R, Ansorge S (1996) CD26 Mediates the Action of HIV-1 Tat Protein on DNA Synthesis and Cytokine production in 0937 Cells. Immunobiology 195: 119–128
Ansorge S, Schön E (1987) Dipeptidyl peptidase IV in human T lymphocytes: an approach to the function of this peptidase in the immune system. In: Peptides and Proteases: Recent Advances, edited by Schowen RL, Barth A. Pergamon Press. Oxford, pp 3–10
Schön E, Demuth HU, Eichmann E, Horst HJ, Körner IJ, Kopp J. Mattem T, Neubert K. Noll F. Ulmer AJ. Barth A, Ansorge S (1989) Dipeptidyl peptidase IV in Human T-Lymphocytes Impaired Induction of Interleukin 2 and Gamma Interferon due to Specific Inhibition of Dipeptidyl peptidase IV. Scand J Immunol 29: 127–132
Reinhold D, Bank U, Bühling F, Neubert K, Mattem T. Ulmer AJ, Flad H-D, Ansorge S (1993) Dipeptidyl peptidase IV (CD26) on human lymphocytes. Synthetic inhibitors of and antibodies against dipeptidyl peptidase IV suppress the proliferation of pokeweed mitogen-stimulated peripheral blood mononuclear cells. and IL-2 and IL-6 production. Immunobiology 188: 403–414
Reinhold D, Bank U, Bühling F, Lendeckel U. Ulmer AJ, Flad H-D, Ansorge S (1994) Transforming growth factor betal (TGF-betal) inhibits DNA synthesis of PWM-stimulated PBMC via suppression of IL-2 and IL-6 production. Cytokine 6: 382–388
Reinhold D, Bank U, Bühling F. Lendeckel U, Ansorge S (1995) Transforming growth factor betal inhibits interleukin-l0 mRNA expression and production in pokeweed mitogen-stimulated peripheral blood mononuclear cells and T cells. Journal of Interferon and Cytokine Research 15: 685–690
Fleischer B (1994) CD26: a surface protease involved in T cell activation. Immunology Today 15: 180–184
Morimoto C, Schlossman SF (1994) CD26• A key costimulatory molecule on CD4 memory T cells. Immunologist 2: 4–7
Morrison ME, Vijayasaradhi S, Engelstein D, Albino AP, Houghton AN (1993) A marker for neoplastic progression of human melanocytes is a cell surface ectopeptidase. J Exp Med 177: 1135–1143
Kameoka J, Tanaka T, Nojima Y, Schlossman SF, Morimoto C (1993) Direct association of adenosine deaminase with a T cell activation antigen, CD26. Science 261: 466–469
Torimoto Y, Dang NH, Vivier E, Tanaka T, Schlossman SF, Morimoto C (1991) Coassociation of CD26 (dipeptidyl peptidase IV) with CD45 on the surface of human T lymphocytes. J Immunol 147: 2514–2517
Mittrücker H-W, Steeg C, Malissen B, Fleischer B (1995) The cytoplasmic tail of the T cell receptor zeta chain is required for signalling via CD26. Eur J Immunol 25: 295–297
Kähne T, Neubert K, Ansorge S (1995) Enzymatic activity of DPIV/CD26 is involved in PMA-induced hyperphosphorylation of p56lck. Immunol Lett 46: 189–193
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Ansorge, S. et al. (1997). CD26/Dipeptidyl Peptidase IV in Lymphocyte Growth Regulation. In: Ansorge, S., Langner, J. (eds) Cellular Peptidases in Immune Functions and Diseases. Advances in Experimental Medicine and Biology, vol 421. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9613-1_17
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DOI: https://doi.org/10.1007/978-1-4757-9613-1_17
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