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Cellular Peptidases in Immune Functions and Diseases pp 117–125Cite as

Molecular Associations Required for Signalling VIA Dipeptidyl Peptidase IV (CD26)

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 421))

Abstract

CD26, or dipeptidyl peptidase IV, is a widely distributed cell surface glycoprotein of approximately 110 kD molecular weight. It is constitutively expressed on a variety of different cell types, particularly on epithelial cells of the intestine, prostate and kidney-proximal tubules1–3. On T cells the expression of CD26 is regulated more stringently. The molecule is absent from the majority of human resting peripheral blood T lymphocytes and is expressed weakly on a fraction of T cells in the blood. Expression increases within two days of T cell activation and increases further after culture in vitro 1. 2. It has been shown to be a suitable marker for T cells activated in vivo 4 and memory T cells have been shown to reside in the CD26+ T cell fraction5. CD26 has several unique properties that distinguish this molecule from related surface proteases:

  1. i.

    the expression of CD26 is tightly regulated in different tissues

  2. ii.

    it is associated with the differentiation and activation status of different cells

  3. iii.

    CD26 is highly conserved among different species6.

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References

  1. Fleischer, B. 1995. Dipeptidylpeptidase iV (CD26) in metabolism and the immune response. Molecular Biology Intelligence Unit. R.G. Landes Co., Austin/Springer Verlag, Berlin, 1–202.

    Google Scholar 

  2. Fleischer, B. 1994. CD26: a surface protease involved in T-cell activation. Immunol. Today 15:180–184.

    Google Scholar 

  3. Yaron, A. and N., F. 1993. Proline dependent structural and biological properties of peptides and proteins. Crit. Rev. Biochem. Mol. Biol. 28:31–81.

    Google Scholar 

  4. Enssle, K. H., and B. Fleischer. 1990. Absence of Epstein-Barr virus-specific, HLA class I1-restricted CD4+ cytotoxic T lymphocytes in infectious mononucleosis. Clin. Exp. Immunol. 79:409–415.

    Google Scholar 

  5. Hafler, D. A., D. A. Fox, and D. Benjamin. 1986. Antigen reactive memory T cells are defined by Ta I. J Immunol. 137:414–418.

    Google Scholar 

  6. Marduet, D., A. M. Bernard, I. Vivier, D. Darmoul, P. Naquet, and M. Pierres. 1992. cDNA cloning for mouse thymocyte-activating molecule. A multifunctional ecto-peptidylpeptidase IV (CD26) included in a subgroup of serine proteases. J. Biol. Chem 267:2200–2208.

    Google Scholar 

  7. Kameoka, J., T. Tanaka, Y. Nojima, S. F. Schlossmann, and C. Morimoto, 1993, Direct association of adenosin desaminase with a T cell activation antigen, CD26. Science 261:566–469.

    Google Scholar 

  8. Torimoto, Y., N. H. Dang, E. Vivier, T. Tanaka, S. F. Schlossmann, and C. Morimoto. 1991. Coassociation of CD26 (dipeptidyl peptidase IV) with CD45 on the surface of human T lymphocytes..1. Immunol, 147:2514–2517

    Google Scholar 

  9. Dang, H. H., Y. Torimoto, K. Sugita, J. F. Daley, P. Schow, C, Prado, S. F. Schlossmann, and C. Morimoto. 1990. Cell surface modulation of CD26 by anti 1F7 monoclonal antibody. Analysis of surface expression and human T cell activation. J Immunol. 145:3963–3971.

    Google Scholar 

  10. Subramanyam, M., W. G. Gutheil, W. W. Bachovchin, and B. T. Huber. 1993. Mechanism of HIV-1 tat induced inhibition of antigen-specific T cell responsiveness. J. Immunol. 150:2544–2553.

    Google Scholar 

  11. Schön, E.. S. Jahn, S. T. Kiessig, H. U. Demuth, K. Neubert, A. Barth, R. von Baehr, and S. Ansorge. 1987. The role of dipeptidylpeptidase IV in human T lymphocyte activation. Inhibitors and antibodies against dipeptidyl peptidase IV suppress lymphocyte proliferation and rmmunglobulin synthesis in vitro Eur J. Immunol. 171821–1826.

    Google Scholar 

  12. Flentke, G. R., E. Munoz, B. T. Huber, A. G. Plaut, C. A. Kenner, and Bachovchin W.W. 1991. inhibition of dipeptidyl aminopeptidase IV (DP-IV) by Xaa-boroPro dipeptides and use of these inhibitors to examine the role of DP-IV in T-cell function. Proc..Natl.Acud.Sci. USA 88:1556–1559.

    Google Scholar 

  13. Kubota, T., G. R. Flentke, W. W. Bachovchin, and B. D. Stollar. 1992. Involvement of dipeptidyl peptidase IV in an in vivo immune response. Clin. Exp. Immunol. 89:192–197.

    Google Scholar 

  14. Morimoto, C., Y. Torimoto, G. Levinson, C. E. Rudd, M. Schrieber, N. H. Dang, N. L. Letvin, and S. F. Schlossmann. 1989. i F7, a novel surface molecule, involved in helper function of T cells. J. Immunol 143:3430–3439.

    Google Scholar 

  15. Tanaka, T., Duke-Cohan, J.S., Kameoka, J., Yaron, A., Lee, I., Schlossmann, S.F., and C. Morimoto. 1994. Enhancement of antigen induced T cell proliferation by soluble CD26 (DPP-IV). Proc Natl. Acad. Sci. USA 91:3082–3086.

    Google Scholar 

  16. Fleischer, B. 1987. A novel pathway of human T cell activation via a 103 kD T cell activation antigen. J. bnmunol. 138:1346–1349.

    Google Scholar 

  17. Fleischer, B., Schendel, D., D. von Steldern. 1986. Triggering of the lethal hit in human cytotoxic T lymphocytes: a functional role for a 103 KD T cell activation antigen. Eue. J. Immunol. 16:741–746.

    Google Scholar 

  18. Hegen, M., G. Niedobitek, C. E. Klein, H. Stein, and B. Fleischer. 1990. The T cell triggering molecule Tp 103 is associated with dipeptidyl aminopeptidase IV activity. J. Immunol. 144:2908–2914.

    Google Scholar 

  19. Vivier, I., D. Marguet, P. Naquet, and e. al. 1991. Evidence that thymocyte-activating molecule is mouse CD26 (dipeptidyl peptidase IV). J. Immunol, 147:447–454.

    Google Scholar 

  20. Hegen, M., D. Camerini, and B. Fleischer. 1993. Function of dipeptidyl peptidase IV (CD26, Tp103) in transfected human T cells. Cell. hnmunol. 146:249–260.

    Google Scholar 

  21. Schrezenmeier, H., and B. Fleischer. 1988. A regulatory role for the CD4 and CDS molecules in T cell activation. J. Immunol. 141:398–403.

    Google Scholar 

  22. Dang, N. H., Y. Torimoto, K. Deusch, S. F. Schlossmann, and C. Morimoto. 1990. Comitogenic effect of solid phase immobilized anti-1F7 on human CD4 T cell activation via CD3 and CD2 pathways. J. Immunol. 144:4092–4100.

    Google Scholar 

  23. Fleischer, B., E. Sturm, J. E. de Vries, and H. Spits. 1988. Triggering of cytotoxic T lymphocytes and NK cells via Tp 103 pathway is dependent on the expression of the T cell receptor/CD3 complex. J. Immunol. 141:1103–1107.

    Google Scholar 

  24. Howard, F. D., P. Moingeon, U. Moebius, D. J. McConkey, B. Yandava, T. E. Gennert, and E. L. Reinherz 1992. The CD3 Ç cytoplasmic domain mediates CD2-induced T cell activation. J.Exp.Med. 176: 139–145.

    Google Scholar 

  25. Reth, M. 1989. Antigen receptor clue. Nature 338:383–384.

    Google Scholar 

  26. Samelson, L. E., M. D. Patel, A. M. Weissman, J. B. Harford, and R. D. Klausner. 1986. Antigen activation of murine T cell induces tyrosine phosphorylation of a polypeptide that is associated with the T cell antigen receptor. Cell 46:1083–1090.

    Google Scholar 

  27. Wegener, A. M. K., F. Letourneur, A. Hoeveler, T. Brocker, F. Luton, and B. Malissen. 1992. The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules. Cell 68:83–95.

    Google Scholar 

  28. Donnadieu, E., A. Trautmann, M. Malissen, J. Trucy, B. Malissen, and E. Vivier. 1994. Reconstitution of CD3 S coupling to calcium mobilization via genetic complementation, J. of Biological Chemistry. 269:32828–32834.

    Google Scholar 

  29. Mittrücker, H. W., C. Steeg, B. Malissen, and B. Fleischer. 1995. The cytoplasmic tail of the T cell receptor chain is required for signaling via CD26. Eue J. Immunol. 25:295–297.

    Google Scholar 

  30. Moingeon, P., J. L. Lucich, D. J. McConkey, F. Letourneur, B. Malissen, J. Kochan, H. C. Chang, H. R. Rodewald, and E. L. Reinherz. 1992. CD3 Ç dependence of the CD2 pathway of activation in T lymphocytes and natural killer cells. Proc.Natl.Acad.Sci. USA 39:1492–1496.

    Google Scholar 

  31. Hegen. M., H. W. Mittrúcker, R. Hug, and B. Fleischer. 1993. Enzymatic activity of CD26 (dipeptidyl peptidase IV) is not required for its signalling function in T cells. lmmunohiol. 189:483–493.

    Google Scholar 

  32. Stecg, C., U. Hartwig, and B. Fleischer. 1995. Unchanged signaling capacity of mutant CD26/Dipeptidyl peptidase IV molecules devoid of enzymatic activity. Cell. Immunol. 164:311–315.

    Google Scholar 

  33. Tanaka, T.. J. Kameoka, A. Yaron, S. F. Schlossmann, and C. Morimoto. 1993. The costirnulatory activity of the CD26 antigen requires dipeptidyl peptidase IV enzymatic activity. Proc. Natl. Acad. Scr_ USA 90:4586–4590.

    Google Scholar 

  34. Grabstein. K.. J. Eisenmann, D. Modizuki, P. Schanebeck, P. Cordon, T. Hopp, C. March, and S. Gilles. 1986. Purification to homogeneity of B cell stimulating factor. J. Exp. ruled. 163’1405–1414.

    Google Scholar 

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Authors and Affiliations

  1. Bernhard Nocht Institute for Tropical Medicine, D-20359, Hamburg, Germany

    Bernhard Fleischer, Christiane Steeg, Jochen Hühn & Arne von Bonin

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  1. Bernhard Fleischer
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  2. Christiane Steeg
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  3. Jochen Hühn
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  4. Arne von Bonin
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Editor information

Editors and Affiliations

  1. Institute of Experimental Internal Medicine, Otto von Guericke University, Magdeburg, Germany

    Siegfried Ansorge

  2. Institute of Medical Immunology, Martin Luther University, Halle, Germany

    Jürgen Langner

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© 1997 Springer Science+Business Media New York

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Fleischer, B., Steeg, C., Hühn, J., von Bonin, A. (1997). Molecular Associations Required for Signalling VIA Dipeptidyl Peptidase IV (CD26). In: Ansorge, S., Langner, J. (eds) Cellular Peptidases in Immune Functions and Diseases. Advances in Experimental Medicine and Biology, vol 421. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9613-1_16

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  • DOI: https://doi.org/10.1007/978-1-4757-9613-1_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9615-5

  • Online ISBN: 978-1-4757-9613-1

  • eBook Packages: Springer Book Archive

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