Skip to main content
SpringerLink
Log in

Structure of CD26 (Dipeptidyl Peptidase IV) and Function in Human T Cell Activation

  • Chapter
Cellular Peptidases in Immune Functions and Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 421))

Abstract

1996 was the 10th anniversary of the establishment of the cluster of differentiation antigen, CD26 by the Second Workshop and Conference on Human Leukocyte Differentiation Antigens1. First described as a T cell activation antigen, CD26 was found to he strongly expressed on subsets of both activated CD4 and CD8 T cells2. Subsequent work showed the expression of CD26 on activated Nk cells, B cells and B cell lines and demonstrated CD26 expression on a variety of different cell types, most abundantly on epithelia of the intestine, prostate and the proximal tubuli of the kidneys3,4,5. Furthermore, it was demonstrated that CD26 possesses enzymatic activity, dipeptidyl peptidase IV (DPP IV; EC 3.4.14.5), in its extracellular domain4 and is identical to the previously described adenosine deaminase (ADA, EC 3.5.4.4) binding protein6,7. Recent studies indicate that CD26 plays a seminal role in T cell costimulation and may be involved in severe combined immunodeficiency and HIV infection 8,9.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Knowles, R. W. 1986. In Leukocyte typing II (ed. E. L. Reinherz, B. F. Haynes, L. M. Nadler. and I. D. Bernstein), Springer-Verlag, New York, pp. 259–88.

    Google Scholar 

  2. Fox, D. A., Hussey, R. E., Fitzgerald, K. A., Acuto, O., Poole, C, Palley, L., Daley, F. J., Schlossman, S. F. and Reinherz, E. L. 1984. Tal, a novel cell surface molecule involved in helper function of CD4 cells. Journal of Immunology 133, 1250–6.

    CAS  Google Scholar 

  3. Stein, H., Schwarting, R. and Niedobitek, G. 1989. In Leukocyte typing IV. (ed. W. Knapp, B. Dörken, W. R. Gilks, E. P. Rieber, R. E. Schmidt, H. Stein, and A. E. G. Kr. von dem Borne), Oxford University Press. Oxford, pp.4I2–5.

    Google Scholar 

  4. Hegen, M., Niedobitek G.. Klein, C. E., Stein, H. and Fleischer, B. 1990. The T cell triggering molecule Tp 103 is associated with dipeptidyl aminopeptidase IV activity. Journal of Immunology 144, 2908–14.

    CAS  Google Scholar 

  5. Bühling, F., Junker, U., Reinhold, D., Neubert, K., Jäger, L. and Ansorge, S. 1995. Functional role of CD26 on human B lymphocytes. Immunology Letters 45, 47–51.

    Article  Google Scholar 

  6. Kameoka, J., Tanaka, T., Nojima, Y., Schlossman, S. F. and Morimoto, C. 1993. Direct association of adenosine deaminase with a T cell activation antigen, CD26. Science 261, 466–9.

    Article  PubMed  CAS  Google Scholar 

  7. Morrison, M. E., Vijayasaradhi, S., Engelstein, D.. Albino, A. P., Houghton, A. N. 1993. A marker for neo-plastic progression of human melanocytes is a cell surface ectopeptidase. Journal of Experimental Medicine 177, 1135–43.

    Article  PubMed  CAS  Google Scholar 

  8. Fleischer, B. 1994. CD26: a surface protease involved in T cell activation. Immunology Today IS, 1804.

    Google Scholar 

  9. Morimoto. C. and Schlossman, S. F. 1994. CD26, a key costimulatory molecule on CD4 memory T cells. The Itnniunologisl 2, 4–7.

    Google Scholar 

  10. Tanaka, T., Camerini, D., Seed, B., Torimoto, Y., Dang, N. H.. Kameoka, J., Dahlberg, H. N., Schlossman, S. F. and Morimoto. C. 1992. Cloning and functional expression of the T cell activation antigen CD26. Journal of Immunology 149, 481–6.

    CAS  Google Scholar 

  11. Darmoul, D., Lacasa, M., Baricault, L., Marguet, D., Sapin, C., Trotot. P. Barbat, A. and Trugnan, G. 1992. Dipeptidyl peptidase IV (CD26) gene expression in enterocyte-like colon cancer cell lines HT-29 and Caco-2. Cloning of the complete human coding sequence and changes of dipeptidyl peptidase IV mRNA levels during cell differentiation. Journal of Biological Chemistry 267, 2200–8.

    Google Scholar 

  12. Hong. W. and Doyle, D. 1987. eDNA cloning for a bile canaliculus domain-specific membrane glycoprotein of rat hepatocytes. Proceedings of the National Academy of Science USA. 84, 7962–65.

    Google Scholar 

  13. Ogata. S., Misumi, Y. and Ikehara, Y. 1989. Primary structure of rat liver dipeptidyl peptidase IV deduced from its eDNA and identification of the NH,-terminal signal sequence as the membrane-anchoring domain. Journal of Biological Chemisnv 264, 3596–601.

    Google Scholar 

  14. Marguet, D., Bernard, A.-M., Vivier, I., Darmoul, D., Naquet, P. and Pierres, M. 1992. cDNA cloning for mouse thymocyte-activating molecule. Journal of Biological Chemistry 267. 2200–8

    Google Scholar 

  15. Abbott, C. A., Baker, E., Sutherland, G. R. and McCaughan, G. W. 1994. Genomic organisation, exact localization, and tissue expression of the human CD26 (dipeptidyl peptidase IV) gene. Immunogenetics 40, 331–8.

    Article  PubMed  CAS  Google Scholar 

  16. Tanaka, T., Kameoka, J., Yaron, A., Schlossman. S. F. and Morimoto, C. 1993. The costimulatory activity of the CD26 antigen requires dipeptidyl peptidase IV enzyme activity. Proceedings of the National Academy of Science USA. 90, 4586–90.

    Article  CAS  Google Scholar 

  17. Kenny, A. J., Booth, A. G., George, S. G.. Ingram, J., Kershaw, D., Wood, E. J. and Young, A. R. 1976. Dipeptidyl peptidase IV, a kidney brush-border serine peptidase. Biochemical Journal 155, 169–82.

    Google Scholar 

  18. Yaron, A. and Naider, F. 1993. Proline-dependent structural and biological properties of peptides and proteins. Critical Review Biochemical Molecular Biology 28, 31–81.

    Article  CAS  Google Scholar 

  19. Torimoto, Y., Dang, N. H., Tanaka, T., Prado, C., Schlossman, S. F. and Morimoto, C. 1992. Biochemical characterization of CD26 (dipeptidyl peptidase IV): Functional comparison of distinct epitopes recognized by various monoclonal antibodies. Molecular Immunology 29, 183–92.

    Article  PubMed  CAS  Google Scholar 

  20. Daddona, P. E., Shewach, D. S., Kelley, W. N., Argos, P., Markham, A.F. and Orkin, S. H. 1984. Human adenosine deaminase: eDNA and complete primary amino acid sequence. Journal Biological Chemistry 259, 12101–6.

    CAS  Google Scholar 

  21. Schrader, W. P., Miczek, A.D., West, C. A. and Samsonoff, W. A. 1988. Evidence for receptor-mediated uptake of adenosine deaminase in rabbit kidney. Journal Histochemistry Cytochemistry 36, 1481–7.

    Article  CAS  Google Scholar 

  22. Aran, J. M., Colomer, D., Matutes, E., Vives-Corrons, J. L. and Franco R. J. 1991. Presence of adenosine deaminase on the surface of mononuclear blood cells: lmmunochemical localization using light and electron microscopy. Journal Histochemisty Cvtochemistry 39, 1001–8.

    Article  CAS  Google Scholar 

  23. Hirschhorn R. 1990. In Immunodefiency Reviews. (eds. Rosen, F.S. and Seligmann, M.), Howard, London. Vol. 2. pp. 175–98.

    Google Scholar 

  24. Dong, R.-R., Kameoka, J., Hegen, M., Tanaka, T., Xu, Y, Schlossman, S. F. and Morimoto, C. 1996. Characterization of adenosine deaminase binding to human CD26 on T cells and its biologic role in immune response. Journal of Immunology 156, 1349–55.

    CAS  Google Scholar 

  25. Martin, M., Huguet, J., Centelles, J. J. and Franco, R. 1995. Expression of ecto-adenosine deaminase and CD26 in human T cells triggered by the TCR-CD3 complex. Possible role of adenosine deaminase as costimulatory molecule. Journal of Immunology 155, 4630–43.

    CAS  Google Scholar 

  26. Geppert, T. D., Davis, L. S., Gur, H., Wacholtz, M. C. and Lipsky, P. E. 1990. Accessory cell signals involved in T cell activation. Immunological Reviews 117, 5–66.

    Article  PubMed  CAS  Google Scholar 

  27. Morimoto, C., Torimoto, Y., Levinson, G., Rudd, C. E., Schrieber, M., Dang, N. H.. Letvin, N. L. and Schlossman, S. F. 1989. I F7, a novel cell surface molecule involved in helper function of CD4 cells. Journal of Immunology 143, 3430–9.

    CAS  Google Scholar 

  28. Fleischer, B. 1987. A novel pathway of human T cell activation via a 103KD human T cell activation antigen. Journal of Immunology 138, 1346–9.

    CAS  Google Scholar 

  29. Dang, N. H., Torimoto, Y., Deusch, K., Schlossman, S. F. and Morimoto, C. 1990. Comitogenic effect of solid-phase immobilized anti-1F7 on human CD4 T cell activation via CD3 and CD2 pathways. Journal of Immunology 144, 4092–100.

    CAS  Google Scholar 

  30. Dang, N. H., Torimoto, Y., Sugita, K., Daley, J. F., Schow, P., Prado, C., Schlossman. S. F. and Morimoto, C. 1990. Cell surface modulation of CD26 by anti-IF7 monoclonal antibody: Analysis of surface expression and human T cell activation. Journal of Immunology 145, 3963–71.

    CAS  Google Scholar 

  31. Hegen, M., Camerini, D. and Fleischer B. 1993. Function of dipeptidyl peptidase IV (CD26, Tp103) in transfected human T cells. Cellular Immunology 146, 249–60.

    Article  PubMed  Google Scholar 

  32. Dang, N. H., Hafler, D. A., Schlossman, S. F. and Breitmeyer, J. B. 1990. FcR-mediated crosslinking of Tal (CDw26) induces T cell activation. Cellular Immunology 125, 42–57.

    Article  PubMed  CAS  Google Scholar 

  33. Chan, A. C., Desai, D. M. and Weiss, A. 1994. The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction. Annual Review immunology 12, 555–92.

    Article  CAS  Google Scholar 

  34. Hafler, D. A., Fox, D. A., Benjamin, D. and Weiner, H. L. 1986. Antigen rective memory T cells arc defined by Tal. Journal of Immunology 147, 414 8.

    Google Scholar 

  35. Munoz, E., Blazquez, M. W.. Madueno. J. A., Rubio, G. and Pena,.1. 1992. CD26 induces T cell proliferation by tyrosine phosphorylation. Immunology 77, 43–50.

    PubMed  CAS  Google Scholar 

  36. Hegen, M., Kameoka, J., Dong, R.-R., Schlossman, S. F. and Morimoto, C. 1997. Cross-linking of CD26 by antibody induces tyrosine phosphorylation and activation of mitogen-activated protein kinase. Immunology 90, 257–64.

    Article  PubMed  CAS  Google Scholar 

  37. Torimoto, Y., Dang, N. H., Vivier, E., Tanaka, T., Schlossman. S. F. and Morimoto, C. 1991. Coassociation of CD26 (dipetidyl peptidase IV) with CD45 on the surface of human T lymphocytes. Journal of Immunology 147, 2514–7.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Tumor Immunology Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, 44 Binney Street, Boston, Massachusetts, 02115, USA

    Martin Hegen, Junichi Kameoka, Rui-Ping Dong, Chikao Morimoto & Stuart F. Schlossman

Authors
  1. Martin Hegen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Junichi Kameoka
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rui-Ping Dong
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Chikao Morimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Stuart F. Schlossman
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute of Experimental Internal Medicine, Otto von Guericke University, Magdeburg, Germany

    Siegfried Ansorge

  2. Institute of Medical Immunology, Martin Luther University, Halle, Germany

    Jürgen Langner

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer Science+Business Media New York

About this chapter

Cite this chapter

Hegen, M., Kameoka, J., Dong, RP., Morimoto, C., Schlossman, S.F. (1997). Structure of CD26 (Dipeptidyl Peptidase IV) and Function in Human T Cell Activation. In: Ansorge, S., Langner, J. (eds) Cellular Peptidases in Immune Functions and Diseases. Advances in Experimental Medicine and Biology, vol 421. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9613-1_15

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-9613-1_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9615-5

  • Online ISBN: 978-1-4757-9613-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation