Aminopeptidase N-Mediated Signal Transduction and Inhibition of Proliferation of Human Myeloid Cells
Cell surface peptidases are involved in degradative processes of various peptides, in cell-cell communcation, in lymphocyte activation and in cell growth1,2,3,4. Aminopeptidase N (APN, CD 13), a ubiquitously occurring surface molecule of many tissues, among them human liver, kidneys, intestine, placenta, bone marrow or brain microvessels, acts with a relatively broad substrate specifity on peptides with N-terminal neutral amino acids 5. Within the haematopoietic system CD13 is localized on monocytes, granulocytes and activated T lymphocytes5,6,7,8.
KeywordsU937 Cell Bath Solution Chelate Zinc Human Myeloid Cell Cell Surface Density
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