Long-Term Potentiation of Synaptic Transmission in the Hippocampus Obeys Hebb’s Rule for Synaptic Modification

  • Holger Wigström
  • Bengt Gustafsson
  • Yan-You Huang


Cellular mechanisms for associative memory are generally assumed to involve synaptic changes dependent on a conjunction between activity in different neuronal elements, and various principles for such conjunctive control of synaptic modification have been proposed (Brindley, 1969; von Baumgarten, 1970). In the model for neuronal memory put forward by Hebb (1949), the strengthening of synaptic connections was postulated to occur as a result of nearly simultaneous firing of the pre- and the postsynaptic cells. Long-term potentiation (LTP) in the hippocampus is a synaptic strengthening process that has been implicated in learning and memory (Bliss and L¢mo, 1973; Teyler and Discenna, 1984), and recent studies have suggested that its induction is controlled by coincident pre- and postsynaptic activity in general agreement with Hebb’s rule for synaptic modification (Wigström et al., 1986; Kelso et al., 1986).


Current Pulse Cell Firing Postsynaptic Cell Synaptic Modification Postsynaptic Spike 
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  1. Bliss, T. V. P., and Lømo, T., 1973, Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path, J. Physiol. (Lond.) 232: 331–356.Google Scholar
  2. Bloch, V., and Laroche, S., 1985, Enhancement of long-term potentiation in the rat dentate gyms by posttrial stimulation of the reticular formation, J. Physiol. (Lond.) 360: 215–231.Google Scholar
  3. Brindley, G. S., 1969, Nerve net models of plausible size that perform many simple learning tasks, Proc. R. Soc. Lond. (Biot) 174: 173–191.CrossRefGoogle Scholar
  4. Gustafsson, B., and Wigström, H., 1986, Hippocampal long-lasting potentiation produced by pairing single volleys and brief conditioning tetani evoked in separate afferents, J. Neurosci. 6: 1575–1582.PubMedGoogle Scholar
  5. Gustafsson, B., Wigström, H., Abraham, W. C., and Huang, Y.-Y., 1987, Long-term potentiation in the hippocampus using depolarizing current pulses as the conditioning stimulus to single volley synaptic potentials, J. Neurosci. 7: 774–780.PubMedGoogle Scholar
  6. Hawkins, R. D., Abrams, T. W., Carew, T. J., and Kandel, E. R., 1983, A cellular mechanism of classical conditioning in Aplysia: Activity-dependent amplification of presynaptic facilitation, Science 219: 400405.Google Scholar
  7. Hebb, D. O., 1949, The Organization of Behavior, John Wiley & Sons, New York.Google Scholar
  8. Kelso, S. R., Ganong, A. H., and Brown, T. H., 1986, Hebbian synapses in hippocampus, Proc. Natl. Acad. Sci. U.S.A, 83: 5326–5330.PubMedCrossRefGoogle Scholar
  9. Malinov, R., and Miller, J. P., 1986, Postsynaptic hyperpolarization during conditioning reversibly blocks induction of long-term potentiation, Nature 320: 529–530.CrossRefGoogle Scholar
  10. Skrede, K. K., and Westgaard, R. H., 1971, The transverse hippocampal slice: A well defined cortical structure maintained in vitro, Brain Res. 35: 589–593.PubMedCrossRefGoogle Scholar
  11. Teyler, T. J., and Discenna, P., 1984, Long-term potentiation as a candidate mnemonic device, Brain Res. Rev. 7: 15–28.CrossRefGoogle Scholar
  12. Baumgarten, R. J., 1970, Plasticity in the nervous system at the unitary level, in: The Neurosciences:Second Study Program ( F. O. Schmitt, ed.), Rockefeller University Press, New York, pp. 260–271.Google Scholar
  13. Wigström, H., 1973, A neuron model with learning capability and its relation to mechanisms of association, Kybernetik 12: 204–215.PubMedCrossRefGoogle Scholar
  14. Wigström, H., 1974, A model of a neural network with recurrent inhibition, Kybernetik 16: 103–112.PubMedCrossRefGoogle Scholar
  15. Wigström, H., 1975, Associative recall and formation of stable modes of activity in neural network models, J. Neurosci. Res. 1: 287–313.PubMedCrossRefGoogle Scholar
  16. Wigström, H., and Gustafsson, B., 1985, On long-lasting potentiation in the hippocampus: A proposed mechanism for its dependence on coincident pre-and postsynaptic activity, Acta Physiol. Scand. 123: 519–522.PubMedCrossRefGoogle Scholar
  17. Wigström, H., and Gustafsson, B., 1987, Presynaptic and postsynaptic interactions in the control of hippocampal long-term potentiation, in: Long-Term Potentiation: From Biophysics to Behavior ( P. W. Landfield and S. Deadwyler, eds.), Alan R. Liss, New York, pp. 71–105.Google Scholar
  18. Wigström, H., Gustafsson, B., Huang, Y.-Y., and Abraham, W. C., 1986, Hippocampal long-term potentiation is induced by pairing single afferent volleys with intracelluarly injected depolarizing current pulses, Acta Physiol. Scand. 126: 317–319.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Holger Wigström
    • 1
  • Bengt Gustafsson
    • 1
  • Yan-You Huang
    • 1
  1. 1.Department of PhysiologyUniversity of GöteborgGöteborgSweden

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