Abstract
Cellular mechanisms for associative memory are generally assumed to involve synaptic changes dependent on a conjunction between activity in different neuronal elements, and various principles for such conjunctive control of synaptic modification have been proposed (Brindley, 1969; von Baumgarten, 1970). In the model for neuronal memory put forward by Hebb (1949), the strengthening of synaptic connections was postulated to occur as a result of nearly simultaneous firing of the pre- and the postsynaptic cells. Long-term potentiation (LTP) in the hippocampus is a synaptic strengthening process that has been implicated in learning and memory (Bliss and L¢mo, 1973; Teyler and Discenna, 1984), and recent studies have suggested that its induction is controlled by coincident pre- and postsynaptic activity in general agreement with Hebb’s rule for synaptic modification (Wigström et al., 1986; Kelso et al., 1986).
Y.-Y. H. is on sabbatical leave from Shanghai Institute of Physiology, Academia Sinica, People’s Republic of China.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bliss, T. V. P., and Lømo, T., 1973, Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path, J. Physiol. (Lond.) 232: 331–356.
Bloch, V., and Laroche, S., 1985, Enhancement of long-term potentiation in the rat dentate gyms by posttrial stimulation of the reticular formation, J. Physiol. (Lond.) 360: 215–231.
Brindley, G. S., 1969, Nerve net models of plausible size that perform many simple learning tasks, Proc. R. Soc. Lond. (Biot) 174: 173–191.
Gustafsson, B., and Wigström, H., 1986, Hippocampal long-lasting potentiation produced by pairing single volleys and brief conditioning tetani evoked in separate afferents, J. Neurosci. 6: 1575–1582.
Gustafsson, B., Wigström, H., Abraham, W. C., and Huang, Y.-Y., 1987, Long-term potentiation in the hippocampus using depolarizing current pulses as the conditioning stimulus to single volley synaptic potentials, J. Neurosci. 7: 774–780.
Hawkins, R. D., Abrams, T. W., Carew, T. J., and Kandel, E. R., 1983, A cellular mechanism of classical conditioning in Aplysia: Activity-dependent amplification of presynaptic facilitation, Science 219: 400405.
Hebb, D. O., 1949, The Organization of Behavior, John Wiley & Sons, New York.
Kelso, S. R., Ganong, A. H., and Brown, T. H., 1986, Hebbian synapses in hippocampus, Proc. Natl. Acad. Sci. U.S.A, 83: 5326–5330.
Malinov, R., and Miller, J. P., 1986, Postsynaptic hyperpolarization during conditioning reversibly blocks induction of long-term potentiation, Nature 320: 529–530.
Skrede, K. K., and Westgaard, R. H., 1971, The transverse hippocampal slice: A well defined cortical structure maintained in vitro, Brain Res. 35: 589–593.
Teyler, T. J., and Discenna, P., 1984, Long-term potentiation as a candidate mnemonic device, Brain Res. Rev. 7: 15–28.
Baumgarten, R. J., 1970, Plasticity in the nervous system at the unitary level, in: The Neurosciences:Second Study Program ( F. O. Schmitt, ed.), Rockefeller University Press, New York, pp. 260–271.
Wigström, H., 1973, A neuron model with learning capability and its relation to mechanisms of association, Kybernetik 12: 204–215.
Wigström, H., 1974, A model of a neural network with recurrent inhibition, Kybernetik 16: 103–112.
Wigström, H., 1975, Associative recall and formation of stable modes of activity in neural network models, J. Neurosci. Res. 1: 287–313.
Wigström, H., and Gustafsson, B., 1985, On long-lasting potentiation in the hippocampus: A proposed mechanism for its dependence on coincident pre-and postsynaptic activity, Acta Physiol. Scand. 123: 519–522.
Wigström, H., and Gustafsson, B., 1987, Presynaptic and postsynaptic interactions in the control of hippocampal long-term potentiation, in: Long-Term Potentiation: From Biophysics to Behavior ( P. W. Landfield and S. Deadwyler, eds.), Alan R. Liss, New York, pp. 71–105.
Wigström, H., Gustafsson, B., Huang, Y.-Y., and Abraham, W. C., 1986, Hippocampal long-term potentiation is induced by pairing single afferent volleys with intracelluarly injected depolarizing current pulses, Acta Physiol. Scand. 126: 317–319.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer Science+Business Media New York
About this chapter
Cite this chapter
Wigström, H., Gustafsson, B., Huang, YY. (1988). Long-Term Potentiation of Synaptic Transmission in the Hippocampus Obeys Hebb’s Rule for Synaptic Modification. In: Woody, C.D., Alkon, D.L., McGaugh, J.L. (eds) Cellular Mechanisms of Conditioning and Behavioral Plasticity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9610-0_6
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9610-0_6
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9612-4
Online ISBN: 978-1-4757-9610-0
eBook Packages: Springer Book Archive