Locus-Coeruleus-Induced Enhancement of the Perforant-Path Evoked Potential

Effects of Intradentate β Blockers
  • Carolyn W. Harley
  • Suzanne Evans


Norepinephrine (NE) iontophoresed in the dentate gyrus of anesthetized rat (Neuman and Harley, 1983) or superfused on the hippocampal slice (Lacaille and Harley, 1985; Stanton and Sarvey, 1986) produces a significant and reliable enhancement of the perforant-pathevoked population spike. This NE-induced enhancement of population spike amplitude can last for many minutes or hours.


Dentate Gyrus Locus Coeruleus Enhancement Effect Perforant Path Population Spike Amplitude 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Carolyn W. Harley
    • 1
  • Suzanne Evans
    • 1
  1. 1.Psychology Department and Faculty of MedicineMemorial University of NewfoundlandSt. JohnsCanada

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