Postsynaptic Events Associated with Long-Lasting Activity-Induced Changes in Excitability of Neocortical Neurons

Studies in the Anesthetized Rat and in Slices in Vitro
  • Lynn J. Bindman
  • Tim Meyer
  • Clive A. Prince


It is well established that changes in excitability of neocortical neurons that persist, undiminished, for tens of minutes can be induced by increasing the firing rate for just a few minutes. Any of a number of experimental procedures can be used to increase firing, including depolarizing current, synaptic activation, and iontophoresis of glutamate or acetylcholine (Burns, 1957; Bindman et al., 1964; Bindman and Boisacq-Schepens, 1966; McCabe, 1973; Woody et al., 1978). The site of the underlying change has been localized to the neocortex in experiments carried out a neuronally isolated slabs of cortex in vivo (Bliss et al., 1968). Both increases and decreases in excitability of different neurons were observed following stimulation in a number of these studies.


Input Resistance Membrane Capacity Interspike Interval Spike Amplitude Neocortical Neuron 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Lynn J. Bindman
    • 1
  • Tim Meyer
    • 1
  • Clive A. Prince
    • 1
  1. 1.Department of PhysiologyUniversity College LondonLondonEngland

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