Abstract
In the first demonstration of long-term potentiation (LTP) by Bliss and Lømo (1973), the conditioning presynaptic stimulation was a brief tetanus (usually 15 Hz for 15 sec) of the perforating pathway to the fascia dentata (Fig. 1A) of the hippocampus, and the homosynaptic stimulation was by a single stimulus through the same electrode; i.e., it was a homosynaptic LTP. Figure 1B illustrates the extracellular potentials recorded either at the level of the synapses and hence largely a negative wave, a population EPSP, or at the level of the granule cell bodies and hence a favorable site for recording the cell discharges, the negative population spike. In Fig. 1C, four bursts of conditioning stimulations cause the population EPSP to increase to more than double and to remain large 10 hr after the last conditioning tetanus.
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References
Akert, K., Peper, K., and Sandri, C., 1975, Structural organization of motor end plate and central synapses, in: Cholinergic Mechanisms ( P. G. Waser, ed.), Raven Press, New York, pp. 43–57.
Barnes, C. A., and McNaughton, B. L., 1980, Spatial memory and hippocampal synaptic plasticity in senescent and middle-aged rats, in: Psychology of Aging ( D. Stein, ed.), Elsevier/North-Holland, Amsterdam, pp. 253–272.
Bliss, T. V. P., and Dolphin, A. C., 1982, What is the mechanism of long-term potentiation in the hippocampus? Trends Neurosci. 5: 289–290.
Bliss, T. V. P., and Gardner-Medwin, A. R., 1973, Long-lasting potentiation of synaptic transmission in the dentate area of the unanesthetized rabbit following stimulation of the perforant path, J. Physiol. (Lond.) 232: 357–374.
Bliss, T. V. P., and Lomo, T., 1973, Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path, J. Physiol. (Lond.) 232: 331–356.
Bloch, V., 1970, Facts and hypotheses concerning memory consolidation processes, Brain Res. 24: 561–575.
Collingridge, G. L., Kehl, S. J., and McLennan, H., 1983, Excitatory amino-acids in synaptic transmission in the Schaffer collateral—commissural pathway of the rat hippocampus. J. Physiol. (Gond.) 334: 33–46.
Dingledine, R., 1983, N-Methyl aspartate activates voltage-dependent calcium conductance in rat hippocampal pyramidal cells, J. Physiol. (Lond.) 343: 385–405.
Eccles, J. C., 1981, The modular operation of the cerebral neocortex considered as the material basis of mental events, Neuroscience 6: 1839–1856.
Eccles, J. C., 1983, Calcium in long-term potentiation as a model for memory, Neuroscience 10: 1071–1081.
Eccles, J. C., 1986, Do mental events cause neural events analogously to the probability fields of quantum mechanics? Proc. R. Soc. Lond. [Biol.] 227: 411–428.
Feldman, M. L., 1984, Morphology of the neocortical pyramidal neuron, in: Cerebral Cortex, Vol. 1 ( A. Peters and E. G. Jones, eds.), Plenum Press, New York, pp. 123–200.
Fifkovâ, E., and Anderson, C. L., 1981, Stimulation-induced changes in dimensions of stalks of dendritic spines in dentate molecular layer, Exp. Neurol. 74: 621–627.
Fifkovâ, E., and van Harreveld, A., 1977, Long-lasting morphological changes in dendritic spines of dentate granular cells following stimulation of the entorhinal area, J. Neurocytol. 6: 211–230.
Fifkovâ, E., Markham, J. A., and Delay, R. J., 1983, Calcium in the spine apparatus of dendritic spines in the dentate molecular layer, Brain Res. 266: 163–168.
Fleischhauer, K., and Detzer, K., 1975, Dendritic bundling in the cerebral cortex, in: Advances in Neurology, Vol. 12 ( G. W. Kreutzberg, ed.), Raven Press, New York, pp. 71–77.
Gustafsson, B., and Wigström, H., 1987, Hippocampal long-lasting potentiation produced by pairing single volleys and brief conditioning tetani evoked in separate afferents, J. Neurosci. 6: 1575–1582.
Gustafsson, B., Wigström, H., Abraham, W. C., and Huang, Y.-Y., 1987, Long-term potentiation in the hippocampus using depolarizing current pulses as the conditioning stimulus to single volley synaptic potentials, J. Neurosci. (in press).
Jack, J. J. B., Redman, S. J., and Wong, K., 1981, The components of synaptic potentials evoked in cat spinal motoneurones by impulses in.Aile group la afferents, J. Physiol. (Lond.) 321: 65–96.
Korn, H., Triller, A., Mallet, A., and Faber, D. S., 1981, Fluctuating responses at a central synapse: n of binomial fit predicts number of stained presynaptic boutons, Science 213: 898–901.
Komhuber, H. H., 1973, Neural control of input into long-term memory: Limbic system and amnestic syndrome in man, in: Memory and Transfer of Information ( H. P. Zippel, ed.), Plenum Press, New York, pp. 122.
Lee, K. S., 1983, Sustained modification of neuronal activity in the hippocampus and cerebral cortex, in: Molecular, Cellular and Behavioural Neurobiology of the Hippocampus ( W. Seifert, ed.), Academic Press, New York, pp. 265–272.
Levy, W. B., and Steward, O., 1979, Synapses as asssociative elements in the hippocampal formation, Brain Res. 175: 233–245.
Levy, W. B., and Steward, O., 1983, Temporal contiguity requirements for long-term associative potentiation/depression in the hippocampus, Neuroscience 8: 791–797.
Lynch, G., and Baudry, M., 1984, The biochemical intermediates in memory formation: A new and specific hypothesis, Science 224: 1057–1063.
Lynch, G., Larson, J., Kelso, S., Barrionirevo, G., and Schottler, F., 1983, Intracellular injections of EGTA block induction of hippocampal long-term potentiation, Nature 305: 719–721.
Margenau, H., 1984, The Miracle of Existence, Ox Bow Press, Woodbridge, CT.
Marr, D., 1970, A theory for cerebral neocortex, Proc. R. Soc. Lond. [Biol.] 176: 161–234.
Mayer, M. L., and Westbrook, G. L., 1985, Divalent cation permeability of N-methyl-D-aspartate channels, Soc. Neurosci. Abstr. 11: 7–85.
McNaughton, B. L., 1982, Long-term synaptic enhancement and short-term potentiation in rat fascia dentata act through different mechanisms, J. Physiol. (Lond.) 324: 249–262.
McNaughton, B. L., Douglas, R. M., and Goddard, G. V., 1978, Synaptic enhancement in fascia dentata: Cooperativity among coactive afferents, Brain Res. 157: 277–293.
Penfield, W., and Perot, P., 1963, The brain’s record of auditory and visual experience, Brain 86: 596–696.
Roland, P. E., and Friberg, L., 1985, Localization of cortical areas activated by thinking, J. Neurophysiol. 53: 1219–1243.
Roland, P. E., Larsen, B., Lassen, N. A., Skinh$j, E., 1980, Supplementary motor area and other cortical areas in organization of voluntary movements in man, J. Neurophysiol. 43: 118–136.
Squire, L. R., 1982, The neuropsychology of human memory, Annu. Rev. Neurosci. 5: 241–273.
Squire, L. R., 1983, The hippocampus and the neuropsychology of memory, in: Molecular, Cellular and Behavioural Neurobiology of the Hippocampus ( W. Seifert, ed.), Academic Press, New York, pp. 491–507.
Szentâgothai, J., 1970, Les circuits neuronaux de l’écorce cérébrale, Bull. Acad. R. Med. Belg. 7: 475–492.
Szentggothai, J., 1978, The neuron network of the cerebral cortex: A functional interpretation, Proc. R. Soc. Lond. [Biol.] 201: 219–248.
Watkins, J. C., 1984, Excitatory amino acids and central synaptic transmission, Trends Pharmacol. Sci. 5: 373–376.
Wigström, H., and Gustafsson, B., 1983a, Facilitated induction of hippocampal long-lasting potentiation during blockade of inhibition, Nature 301: 603–604.
Wigström, H., and Gustafsson, B., 1983b, Heterosynaptic modulation of homosynaptic long-lasting potentiation in the hippocampal slice, Acta Physiol. Scand. 119: 455–458.
Wigström, H., and Gustafsson, B., 1984, A possible correlate of the postsynaptic condition for long-lasting potentiation in the guinea pig hippocampus in vitro, Neurosci. Leu. 44: 327–333.
Wigström, H., and Gustafsson, B., 1985a, Facilitation of hippocampal long-lasting potentiation by GABA antagonists, Acta Physiol. Scand. 125: 159–172.
Wigström, H., and Gustafsson, B., 1985b, On long-asting potentiation in the hippocampus: A proposed mechanism for its dependence on coincident pre-and postsynaptic activity, Acta Physiol. Scand. 123: 519–522.
Wigström, H., Gustafsson, B., and Huang, Y.-Y., 1985, A synaptic potential following single volleys in the hippocampal CA, region possibly involved in the induction of long-lasting potentiation, Acta Physiol. Scand. 124: 475–478.
Wigström, H., Gustafsson, B., and Hunag, Y.-Y., 1986, Mode of action of excitatory amino acid receptor antagonists on hippocampal long-lasting potentiation, Neuroscience 17: 1105–1115.
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Eccles, J.C. (1988). Mammalian Systems for Storing and Retrieving Information. In: Woody, C.D., Alkon, D.L., McGaugh, J.L. (eds) Cellular Mechanisms of Conditioning and Behavioral Plasticity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9610-0_28
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