Some Conclusions Relevant to Plasticity Derived from Normal Anatomy

  • Almut Schüz


The cerebral cortex is supposed to be heavily involved in learning processes and has, therefore, been the object of many deprivation studies. However, even the study of the normal, not artifically perturbed brain during and after development may contribute to the question of anatomic traces of plasticity. The advantage of this alternative approach is that it is not necessary to expose animals to an artificial situation in which it may be difficult to distinguish between direct effects of learning and more indirect effects connected with the general condition of the animal. Here I summarize the results we have collected in recent years.


Cerebral Cortex Purkinje Cell Pyramidal Cell Dendritic Spine Cerebellar Cortex 
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  1. Abercrombie, M., 1946, Estimation of nuclear population from microtome sections, Anat. Rec. 94: 239–247.PubMedCrossRefGoogle Scholar
  2. Albus, J. S., 1971, A theory of cerebellar function, Math. Biosci. 10: 25.CrossRefGoogle Scholar
  3. Fifkovâ, E., 1968, Changes in the visual cortex of rats after unilateral deprivation, Nature 220: 379–380.PubMedCrossRefGoogle Scholar
  4. Glickstein, M., and May, J., 1982, Visual control of movement: The circuits which link visual to motor areas of the brain with special reference to the visual input to pons and cerebellum, in: Sensory Physiology ( W. D. Neff, ed.), Academic Press, New York, pp. 103–145.Google Scholar
  5. Globus, A., Rosenzweig, E., Bennett, L., and Diamond, M. C., 1973, Effects of differential experience on dendritic spine counts in rat cerebral cortex, J. Comp. Physiol. Psychol. 82: 175–181.PubMedCrossRefGoogle Scholar
  6. Ito, M., Sakurai, M., and Tongroach, P., 1982, Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cells, J. Physiol. (Lond.) 324:113–134.Google Scholar
  7. Larramendi, L. M. H., 1969, Analysis of synaptogenesis in the cerebellum of the mouse, in: Neurobiology of Cerebellar Evolution and Development (R. Llinâs, ed.), American Medical Association, Chicago, pp. 803–843.Google Scholar
  8. Man, D., 1968, A theory of cerebellar cortex, J. Physiol. (Land.) 202: 437–470.Google Scholar
  9. Peters, A., and Fairén, A., 1978, Smooth and sparsely-spined stellate cells in the visual cortex of the rat: A study using a combined Golgi—electron microscope technique, J. Comp. Neurol. 181:129–172.Google Scholar
  10. Peters, A., and Feldman, L., 1977, The projection of the lateral geniculate nucleus to area 17 of the rat cerebral cortex. IV. Termination upon spiny dendrites, J. Neurocytol. 6: 669–689.PubMedCrossRefGoogle Scholar
  11. Rutledge, L. T., Wright, C., and Duncan, J., 1974, Morphological changes in pyramidal cells of mammalian neocortex associated with increased use, Exp. Neurol. 44: 209–228.Google Scholar
  12. Schapiro, S., and Vukovich, K. R., 1970, Early experience effects upon cortical dendrites: A proposed model for development, Science 167: 292–294.PubMedCrossRefGoogle Scholar
  13. Schüz, A., 1976, Pyramidal cells with different densities of dendritic spines in the cortex of the mouse, Z. Naturforsch. 31C:319–323.Google Scholar
  14. Schüz, A., 1981, Pränatale Reifung and postnatale Veränderungen im Cortex des Meerschweinchens: Mikroskopische Auswertung eines natürlichen Deprivationsexperimentes (English summary), J. Hirnforsch. 22: 93–127.PubMedGoogle Scholar
  15. Schüz, A., 1986, Comparison between the dimensions of dendritic spines in the cerebral cortex of newborn and adult guinea pigs, J. Comp. Neurol. 224: 277–285.CrossRefGoogle Scholar
  16. Schüz, A., and Dortenmann, M., 1987, Synaptic density on non-spiny dendrites in the cerebral cortex of the house mouse. A phosphotungstic acid study, J. Hirnforsch. 28:(in press).Google Scholar
  17. Schüz, A., and Hein, F. M., 1984, Comparison between the developmental calendars of the cerebral and cerebellar cortices in a precocial and an altricial rodent, in: Cerebellar Functions ( J. R. Bloedel, J. Dichgans, and W. Precht, eds.), Springer-Verlag, Berlin, Heidelberg, New York, pp. 318–321.CrossRefGoogle Scholar
  18. Somogyi, P. and Cowey, A., 1981, Combined Golgi and electron microscopic study on the synapses formed by double bouquet cells in the visual cortex of the cat and monkey, J. Comp. Neurol. 195:547–566.Google Scholar
  19. Valverde, F., 1967, Apical dendritic spines of the visual cortex and light deprivation in the mouse, Exp. Brain Res. 3: 337–352.PubMedCrossRefGoogle Scholar
  20. Valverde, F., 1971, Rate and extent of recovery from dark rearing in the visual cortex of the mouse, Brain Res. 33:1–11.Google Scholar
  21. Vaughan, D. W., and Peters, A., 1973, A three-dimensional study of layer I of the rat parietal cortex, J. Comp. Neurol. 149: 355–370.PubMedCrossRefGoogle Scholar
  22. White, E. L., and Hersch, S. M., 1981, Thalamocortical synapses of pyramidal cells which project from SmI to MsI cortex in the mouse, J. Comp. Neurol. 198:167–181.Google Scholar
  23. Winkelmann, E., Brauer, K., and Werner, L., 1976, Untersuchungen zu Spineveränderungen der Lamina-VPyramidenzellen im visuellen Kortex junger und subadulter Laborratten nach Dunkelaufzucht und Zerstörung des Corpus geniculatum laterale, pars dorsalis, J. Hirnforsch. 17: 495–506.Google Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Almut Schüz
    • 1
  1. 1.Max Planck Institute for Biological CyberneticsTübingenFederal Republic of Germany

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